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Tregalizumab

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Pharmaceutical compound
Tregalizumab
Monoclonal antibody
TypeWhole antibody
SourceHumanized
TargetCD4
Clinical data
Other namesBT-061
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
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Tregalizumab is an immunomodulator. It is also known as BT-061. Tregalizumab binds to domain 2 of CD4, and activates Regulatory T cells (Tregs).

References

  1. World Health Organization (2010). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 104" (PDF). WHO Drug Information. 24 (4).
  2. Helling B, König M, Dälken B, Engling A, Krömer W, Heim K, et al. (April 2015). "A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway". Immunology and Cell Biology. 93 (4): 396–405. doi:10.1038/icb.2014.102. PMC 4407014. PMID 25512343.
  3. König M, Rharbaoui F, Aigner S, Dälken B, Schüttrumpf J (Jan 2016). "Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells". Frontiers in Immunology. 7: 11. doi:10.3389/fimmu.2016.00011. PMC 4724712. PMID 26834751.
Monoclonal antibodies for the immune system
Immune system
Human
Mouse
Chimeric
Humanized

Immune activation: Dostarlimab
Other: Ibalizumab

Chimeric + humanized
Interleukin
Human
Humanized
Veterinary
Inflammatory lesions
Mouse
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