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Fletikumab

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Monoclonal antibody Pharmaceutical compound

Fletikumab
Monoclonal antibody
Type	?
Target	IL20
Clinical data
Other names	NNC0109-0012
ATC code	none
Identifiers
CAS Number	1357158-22-5
ChemSpider	none
UNII	82WG3POL9W
KEGG	D11756
ChEMBL	ChEMBL3301580
Chemical and physical data
Formula	C₆₄₉₄H₁₀₀₀₀N₁₇₂₈O₂₀₅₀S₄₄
Molar mass	146492.12 g·mol

Fletikumab (NNC0109-0012) (INN) is a monoclonal antibody designed for the treatment of rheumatoid arthritis that targets IL-20.

This drug was being developed by Novo Nordisk A/S until Novo ceased work in inflammation.

References

World Health Organization (2013). "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed INN: List 110" (PDF). WHO Drug Information. 27 (4).
Statement On A Nonproprietary Name Adopted By The USAN Council - Fletikumab, American Medical Association.
Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, Taylor PC, Senolt L, Deleuran B (2018). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. PMC 6167463. PMID 30319661.

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Interleukin receptor modulators

Decoy receptors: Rilonacept (IL-1 Trap)

Antagonists: Pitrakinra

Antibodies: Dupilumab
Pascolizumab

Agonists: Interleukin 5

Antagonists: YM-90709

Antisense oligonucleotides: TPI ASM8

Agonists: Atexakin alfa
Interleukin 6

Agonists: Interleukin 7

See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.

Agonists: Interleukin 9

Antibodies: Enokizumab

Agonists: Ilodecakin
Interleukin 10 (CSIF)

Agonists: Interleukin 11 (AGIF)
Oprelvekin

Agonists: Edodekin alfa
Interleukin 12

Antibodies: Briakinumab
Ustekinumab

Agonists: ALT-803
Interleukin 15

Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)

Binding proteins: IL18BP

Antibodies: Fletikumab (against IL-20)

Agonists: Denenicokin
Interleukin 21

Antibodies: NNC0114-0005
NNC0114-0006

Agonists: Interleukin 22

Antibodies: Fezakinumab (against IL-22)

Agonists: Interleukin 23 (SGRF)

Agonists: Interleukin 27 (interleukin 30)

Agonists: Interleukin 31

Agonists: Interleukin 33

Agonists: Interleukin 36 (α, β, γ)
Interleukin 38

Antagonists: IL-36RA

Others

See here instead.

Others

Interleukin 14 (taxilin alpha, HMW-BCGF)
Interleukin 16 (signals through CD4)
Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
Interleukin 32
Interleukin 34 (signals through M-CSFR/CSF1R)
Interleukin 35

Unsorted: Efavaleukin alfa
Efineptakin alfa

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