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Interleukin 20 receptor, beta subunit

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Protein-coding gene in the species Homo sapiens

IL20RB
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4DOH

Identifiers
AliasesIL20RB, DIRS1, FNDC6, IL-20R2, Interleukin 20 receptor, beta subunit, interleukin 20 receptor subunit beta
External IDsOMIM: 605621; MGI: 2143266; HomoloGene: 86034; GeneCards: IL20RB; OMA:IL20RB - orthologs
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)
Chromosome 3 (human)Genomic location for IL20RBGenomic location for IL20RB
Band3q22.3Start136,946,230 bp
End137,011,085 bp
Gene location (Mouse)
Chromosome 9 (mouse)
Chr.Chromosome 9 (mouse)
Chromosome 9 (mouse)Genomic location for IL20RBGenomic location for IL20RB
Band9|9 E3.3Start100,339,772 bp
End100,368,841 bp
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of arm

  • skin of abdomen

  • skin of thigh

  • human penis

  • skin of hip

  • gingival epithelium

  • vulva

  • mucosa of pharynx

  • nipple

  • oral cavity
Top expressed in
  • lip

  • skin of external ear

  • esophagus

  • cerebellar cortex

  • skin of back

  • skin of abdomen

  • morula

  • lobe of cerebellum

  • cerebellar vermis

  • embryo
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

53833

213208

Ensembl

ENSG00000174564

ENSMUSG00000044244

UniProt

Q6UXL0

E9Q9A6

RefSeq (mRNA)

NM_144717

NM_001033543
NM_001037246

RefSeq (protein)

NP_653318

NP_001028715

Location (UCSC)Chr 3: 136.95 – 137.01 MbChr 9: 100.34 – 100.37 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 20 receptor, beta subunit (IL20R2 or IL20RB) is a subunit of the interleukin-20 receptor and interleukin-22 receptor. It is believed to be involved in both pro-inflammatory and anti-inflammatory responses.

IL20RB is found in many organ resident effector cells such as keratinocytes at the skin epidermis, osteoclasts, found in bones, and epithelial cells of the intestine and trachea. IL20RB is also found in some immune cells. The subunit has been linked with multiple diseases, including gastrointestinal diseases and glaucoma.

Structure and function

IL20RB is a β-chain with a short intracellular domain. IL20RB, along with the IL-20 receptor, alpha subunit, form the heterodimeric type I interleukin-20 receptor, which binds the cytokines IL-19, IL-20 and IL-24. IL20RB also associates with IL-22 receptor, to form the heterodimeric type II interleukin-20 receptor, which also binds IL-20 and IL-24.

Signaling

After a cytokine binds both the IL20RB and the alpha subunit of the IL20 receptor, a signal is sent through the JAK-STAT signaling pathway. This signaling pathway leads STAT to act as a transcription factor, which can gene expression.

Link to Immune System and Disease

IL20RB mRNA is present in some immune cells, including monocytes, natural killer cells, B-cells, T-cells, and some hematopoietic stem cells. It is known what role IL20RB plays in these cells.

IL20RB is linked with atherosclerosis and gastrointestinal diseases, although its specific roles are unknown.

Glaucoma

IL20RB mRNA is expressed in retinal ganglion cells and optic nerves in rats. Mutations in the IL20RB gene are associated with glaucoma. The specific links between IL20RB and glaucoma are unknown, but IL20RB does not have a causative effect on the disease, instead contributing to an increased risk of the disease along with other factors, such as intraocular pressure.

References

  1. ^ GRCh38: Ensembl release 89: ENSG00000174564Ensembl, May 2017
  2. ^ GRCm38: Ensembl release 89: ENSMUSG00000044244Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rutz S, Wang X, Ouyang W (December 2014). "The IL-20 subfamily of cytokines--from host defence to tissue homeostasis". Nature Reviews. Immunology. 14 (12): 783–795. doi:10.1038/nri3766. PMID 25421700. S2CID 29114703.
  6. ^ Wegenka UM (October 2010). "IL-20: biological functions mediated through two types of receptor complexes". Cytokine & Growth Factor Reviews. 21 (5): 353–363. doi:10.1016/j.cytogfr.2010.08.001. PMID 20864382.
  7. Kragstrup TW, Andersen T, Heftdal LD, Hvid M, Gerwien J, Sivakumar P, et al. (2018-09-25). "The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis". Frontiers in Immunology. 9: 2226. doi:10.3389/fimmu.2018.02226. PMC 6167463. PMID 30319661.
  8. Wirtz MK, Keller KE (2016-01-20). "The Role of the IL-20 Subfamily in Glaucoma". Mediators of Inflammation. 2016: 4083735. doi:10.1155/2016/4083735. PMC 4745377. PMID 26903709.

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q6UXL0 (Interleukin-20 receptor subunit beta) at the PDBe-KB.
Cytokine receptors
Chemokine receptor
(GPCRs)
CC
CXC
Other
TNF receptor
1-10
11-20
21-27
JAK-STAT
Type I
γ-chain
β-chain
gp130
IL12RB1
Other
Type II
Ig superfamily
IL 17 family
Enzyme-linked receptor
Interleukin receptor modulators
IL-1
IL-2
IL-3
IL-4
IL-5
IL-6
IL-7
IL-8
  • See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
IL-9
IL-10
IL-11
IL-12
IL-13
IL-15
IL-17
IL-18
IL-20
IL-21
IL-22
IL-23
IL-27
IL-28
IL-31
IL1RL1
IL1RL2
Others
JAK
Others
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