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Hydroflumethiazide

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Chemical compound Pharmaceutical compound
Hydroflumethiazide
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
ATC code
Identifiers
IUPAC name
  • 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.704 Edit this at Wikidata
Chemical and physical data
FormulaC8H8F3N3O4S2
Molar mass331.28 g·mol
3D model (JSmol)
SMILES
  • FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N
InChI
  • InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
  • Key:DMDGGSIALPNSEE-UHFFFAOYSA-N
  (verify)

Hydroflumethiazide (or Saluron) is a diuretic.

Synthesis

Hydroflumethiazide synthesis: Numerous patents, e.g., Lund et al., U.S. patent 3,254,076 (1966 to Lövens Kemiske Fabrik).

See also

References

  1. Holdrege CT, Babel RB, Cheney LC (1959). "Synthesis of Trifluoromethylated Compounds Possessing Diuretic Activity1". Journal of the American Chemical Society. 81 (18): 4807–4810. doi:10.1021/ja01527a015.
  2. Close WJ, Swett LR, Brady LE, Short JH, Vernsten M (1960). "Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society. 82 (5): 1132–1135. doi:10.1021/ja01490a028.
  3. Novello FC, Bell SC, Abrams EL, Ziegler C, Sprague JM (1960). "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of Organic Chemistry. 25 (6): 970–981. doi:10.1021/jo01076a028.
Symporter inhibitors
Na-Cl
Na-K-Cl
See also: Receptor/signaling modulators
Diuretics (C03)
Sulfonamides
(and etacrynic acid)
CA inhibitors (at PT)
Loop (Na-K-Cl at AL)
Thiazides (Na-Cl at DCT,
Calcium-sparing)
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT, DL)
Vasopressin receptor inhibitors
(DCT and CD)
Other
Combination products


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