The WIPI protein family (WD-repeat protein Interacting with PhosphoInositides) is an evolutionarily conserved family of proteins. WIPI proteins contain a WD repeat domain that folds into a 7-bladed beta-propeller that functions in autophagy, and contain a conserved motif for interaction with phospholipids.
Members of this family include:
| Protein | Gene | Aliases | Yeast |
|---|---|---|---|
| WIPI-1 | WIPI1 | WIPI49, FLJ10055 | Atg18 |
| WIPI-2 | WIPI2 | Svp1a, DKFZP434J154 WIPI49-like protein 2 | Atg21 |
| WIPI-3 | WDR45L | 628 protein, WIPI49-like protein | |
| WIPI-4 | WDR45 | JM5 protein, WDRX1 |
References
- ^ Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). "WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy". Oncogene. 23 (58): 9314–25. doi:10.1038/sj.onc.1208331. PMID 15602573. S2CID 22642893.
- "Entrez Gene: WIPI2 WD repeat domain, phosphoinositide interacting 2".
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