The type IV filament superfamily (TFF) is a group of fibrous protein structures that includes a set of cell projections with evolutionarily related membrane proteins. The TFF family seems to have originated in the last universal common ancestor, from where it diversified into archaella, type IV pili, type II secretion systems, and the Tad pili.
Complexes in the TFF superfamily are unified by the presence of the eponymous type IV pilin, an AAA+ ATPase, an integral (cytoplasmic) membrane (IM) platform, and (with the exception of MSH) a prepilin peptidase.
References
- Berry JL, Pelicic V (January 2015). "Exceptionally widespread nanomachines composed of type IV pilins: the prokaryotic Swiss Army knives". FEMS Microbiology Reviews. 39 (1): 134–54. doi:10.1093/femsre/fuu001. PMC 4471445. PMID 25793961.
- ^ Denise R, Abby SS, Rocha EP (July 2019). Beeby M (ed.). "Diversification of the type IV filament superfamily into machines for adhesion, protein secretion, DNA uptake, and motility". PLOS Biology. 17 (7): e3000390. doi:10.1371/journal.pbio.3000390. PMC 6668835. PMID 31323028.
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