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TBC1D3

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Protein-coding gene in the species Homo sapiens

TBC1D3F

Identifiers

TBC1D3F, TBC1D3, TBC1D3G, TBC1 domain family member 3F

External IDs

OMIM: 610809; HomoloGene: 74280; GeneCards: TBC1D3F; OMA:TBC1D3F - orthologs

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17q12	Start	36,428,618 bp
Band	17q12	End	36,439,566 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

right testis

left testis

right uterine tube

left uterine tube

bone marrow

duodenum

skeletal muscle tissue

gallbladder

blood

n/a

More reference expression data


More reference expression data

Gene ontology
Molecular function	GTPase activator activity
Cellular component	membrane plasma membrane intracellular anatomical structure endomembrane system
Biological process	intracellular protein transport regulation of vesicle fusion activation of GTPase activity
Sources:Amigo / QuickGO

Species

Human

Mouse


84218


n/a


ENSG00000275954


n/a


A6NER0


n/a

RefSeq (mRNA)


NM_032258


n/a

RefSeq (protein)


NP_115634


n/a

Location (UCSC)

Chr 17: 36.43 – 36.44 Mb

n/a

PubMed search

n/a

View/Edit Human

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene.

This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking. There are two copies of this gene located within a cluster of chemokine genes on chromosome 17q; this record represents the more centromeric copy.

References

^ GRCh38: Ensembl release 89: ENSG00000275954 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hodzic D, Kong C, Wainszelbaum MJ, Charron AJ, Su X, Stahl PD (Nov 2006). "TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12". Genomics. 88 (6): 731–6. doi:10.1016/j.ygeno.2006.05.009. PMID 16863688.
^ "Entrez Gene: TBC1D3 TBC1 domain family, member 3".

Further reading

Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene. 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID 8406013.
Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID 8471161.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. Bibcode:2003PNAS..100.2507P. doi:10.1073/pnas.0437015100. PMC 151371. PMID 12604796.
Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC 149457. PMID 12612085.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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