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STXBP3
Identifiers
Aliases	STXBP3, MUNC18-3, MUNC18C, PSP, UNC-18C, Syntaxin binding protein 3
External IDs	OMIM: 608339; MGI: 107362; HomoloGene: 5260; GeneCards: STXBP3; OMA:STXBP3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p13.3 Start 108,746,674 bp End 108,809,523 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F3 Start 108,700,492 bp End 108,747,842 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum Achilles tendon tibia C1 segment germinal epithelium epithelium of nasopharynx inferior ganglion of vagus nerve monocyte sural nerve palpebral conjunctiva Top expressed in skin of external ear stroma of bone marrow Epithelium of choroid plexus ascending aorta sciatic nerve jejunum aortic valve retinal pigment epithelium transitional epithelium of urinary bladder lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin-1 binding protein binding syntaxin binding Cellular component cytoplasm platelet alpha granule cytosol membrane tertiary granule plasma membrane basolateral plasma membrane specific granule apical plasma membrane extracellular exosome phagocytic vesicle presynapse Biological process protein to membrane docking protein heterooligomerization neutrophil degranulation insulin secretion vesicle docking involved in exocytosis response to insulin brain development negative regulation of calcium ion-dependent exocytosis protein transport platelet aggregation vesicle-mediated transport exocytosis transport cellular glucose homeostasis negative regulation of glucose import cellular response to interferon-gamma Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6814 20912 Ensembl ENSG00000116266 ENSMUSG00000027882 UniProt O00186 Q60770 RefSeq (mRNA) NM_007269 NM_011504 RefSeq (protein) NP_009200 NP_035634 Location (UCSC) Chr 1: 108.75 – 108.81 Mb Chr 3: 108.7 – 108.75 Mb PubMed search
Wikidata
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Syntaxin-binding protein 3 is a protein that in humans is encoded by the STXBP3 gene.

Interactions

Syntaxin binding protein 3 has been shown to interact with STX2 and STX4.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000116266 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000027882 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reed GL, Houng AK, Fitzgerald ML (April 1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. doi:10.1182/blood.V93.8.2617. PMID 10194441.
6. "Entrez Gene: STXBP3 syntaxin binding protein 3".
7. ^ Schraw TD, Lemons PP, Dean WL, Whiteheart SW (August 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". The Biochemical Journal. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
8. Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (November 1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". The Journal of Neuroscience. 16 (21): 6695–702. doi:10.1523/JNEUROSCI.16-21-06695.1996. PMC 6579271. PMID 8824310.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (August 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
• Widberg CH, Bryant NJ, Girotti M, Rea S, James DE (September 2003). "Tomosyn interacts with the t-SNAREs syntaxin4 and SNAP23 and plays a role in insulin-stimulated GLUT4 translocation". The Journal of Biological Chemistry. 278 (37): 35093–101. doi:10.1074/jbc.M304261200. PMID 12832401.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Fu J, Naren AP, Gao X, Ahmmed GU, Malik AB (February 2005). "Protease-activated receptor-1 activation of endothelial cells induces protein kinase Calpha-dependent phosphorylation of syntaxin 4 and Munc18c: role in signaling p-selectin expression". The Journal of Biological Chemistry. 280 (5): 3178–84. doi:10.1074/jbc.M410044200. PMID 15576373.
• Hodgkinson CP, Mander A, Sale GJ (June 2005). "Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking". The Biochemical Journal. 388 (Pt 3): 785–93. doi:10.1042/BJ20041845. PMC 1183457. PMID 15707389.

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