SPRM may refer to:
Science
- Sprm1, a POU domain protein also known as POU5F2
- Selective progesterone receptor modulator
- Surface plasmon resonance microscopy
Other
- Malaysian Anti-Corruption Commission (Suruhanjaya Pencegahan Rasuah Malaysia)
- Somali People's Resistance Movement (Al-Shabaab)
- Capitán FAP Leonardo Alvariño Herr Airport (IATA code)
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