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RAM-378

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Chemical compound Pharmaceutical compound
RAM-378
Identifiers
IUPAC name
  • 3,6,14-trihydroxy-4,5α-epoxy-17-(2-phenylethyl)morphinan
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC24H27NO4
Molar mass393.483 g·mol
3D model (JSmol)
SMILES
  • C1C2(3CC4=C52(CCN3CCC6=CC=CC=C6)(1O)OC5=C(C=C4)O)O
InChI
  • InChI=1S/C24H27NO4/c26-17-7-6-16-14-19-24(28)10-8-18(27)22-23(24,20(16)21(17)29-22)11-13-25(19)12-9-15-4-2-1-3-5-15/h1-7,18-19,22,26-28H,8-14H2/t18-,19+,22-,23-,24+/m0/s1
  • Key:GAHRZWMAHDWVCL-VKJMTUIMSA-N
  (verify)

RAM-378(7,8-Dihydro-14-hydroxy-N-phenethylnormorphine) is an opioid analgesic. It is the N-phenethyl derivative of hydromorphinol.

See also

References

  1. Ben Haddou T, Béni S, Hosztafi S, Malfacini D, Calo G, Schmidhammer H, Spetea M (2014). "Pharmacological investigations of N-substituent variation in morphine and oxymorphone: opioid receptor binding, signaling and antinociceptive activity". PLOS ONE. 9 (6): e99231. Bibcode:2014PLoSO...999231B. doi:10.1371/journal.pone.0099231. PMC 4053365. PMID 24919067.
Opioid receptor modulators
μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others
  • Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)


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