| Antimicrobial12 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Antimicrobial12 | ||||||||
| Pfam | PF08107 | ||||||||
| InterPro | IPR012515 | ||||||||
| TCDB | 1.C.62 | ||||||||
| OPM superfamily | 142 | ||||||||
| OPM protein | 1z64 | ||||||||
| |||||||||
Pleurocidin is an antimicrobial peptide found in the mucus secreted by the skin of the winter flounder (Pleuronectes americanus). It exhibits broad-spectrum antimicrobial activity. Pleurocidin assumes an amphipathic alpha-helical conformation similar to other linear antimicrobial peptides and may play a role in innate host defence.
Potential Applications
Pleurocidin has been noted for its potential use in food safety, in part due to its heat stable properties and clinically demonstrated effectiveness against common food-borne microorganisms.
References
- Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66 – FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.
- Cole AM, Weis P, Diamond G (May 1997). "Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder". J. Biol. Chem. 272 (18): 12008–13. doi:10.1074/jbc.272.18.12008. PMID 9115266.
- Burrowes, O. J.; Hadjicharalambous, C.; Diamond, G.; Lee, Tung-Ching (2004-04-01). "Evaluation of Antimicrobial Spectrum and Cytotoxic Activity of Pleurocidin for Food Applications". Journal of Food Science. 69 (3): FMS66 – FMS71. doi:10.1111/j.1365-2621.2004.tb13373.x. ISSN 1750-3841.