"Perfidia" is a popular Mexican song.
It may also refer to:
- Perfidia (Rossner novel), by Judith Rossner
- Perfidia (Ellroy novel), by James Ellroy, published in 2014
- "Perfidia" (Journeyman), an episode of the TV show Journeyman
- The Man in Grey, a 1943 British drama film released in Spain and Portugal as Perfidia
- Les Dames du Bois de Boulogne, a 1945 French film released in Italy as Perfidia
- Perfidia (film), a 2009 Bolivian film directed by Rodrigo Bellott, starring Gonzalo Valenzuela
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