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PI15
Identifiers
Aliases	PI15, CRISP8, P24TI, P25TI, peptidase inhibitor 15
External IDs	OMIM: 607076; MGI: 1934659; HomoloGene: 22935; GeneCards: PI15; OMA:PI15 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.13 Start 74,824,534 bp End 74,855,029 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 A3 Start 17,672,125 bp End 17,701,163 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis lactiferous duct appendix left uterine tube seminal vesicula cartilage tissue smooth muscle tissue prostate visceral pleura urethra Top expressed in ascending aorta aortic valve glomerulus uterus decidua tunica media of zone of aorta Bowman's capsule vas deferens esophagus endothelial cell of lymphatic vessel More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase inhibitor activity Cellular component extracellular exosome extracellular region extracellular space Biological process negative regulation of peptidase activity multicellular organism development biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51050 94227 Ensembl ENSG00000137558 ENSMUSG00000067780 UniProt O43692 Q8BS03 RefSeq (mRNA) NM_015886 NM_001324403 NM_053191 RefSeq (protein) NP_001311332 NP_056970 NP_444421 Location (UCSC) Chr 8: 74.82 – 74.86 Mb Chr 1: 17.67 – 17.7 Mb PubMed search
Wikidata
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Peptidase inhibitor 15 is a protein that in humans is encoded by the PI15 gene.

Function

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. .

References

1. ^ GRCh38: Ensembl release 89: ENSG00000137558 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000067780 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Peptidase inhibitor 15". Retrieved 2018-08-01.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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