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Michielin explained the lyrical content of "Nessun grado di separazione" in several interviews, claiming that the song is inspired by the six degrees of separation theory and contains the message that, "despite all of the cultural differences, there shouldn't be distances between people".
Particularly, the composition's verses, biographical and introspective, tell the story of "a girl who lives in a drawer together with all her crumpled dreams, and who, at a certain point, finds the courage to come out from that shelter to face the true life", with the will to open herself to the outside world, overcoming fears and preconceptions.
Michielin also added that she recorded background vocals for the track on the same day of the November 2015 Paris attacks, therefore she was furthermore inspired to reflect on the song's lyrics and on "all the barriers that exist between people, while the truth is that we are all human beings with dreams and hopes".
Sanremo Music Festival and Eurovision Song Contest
On 13 December 2015, during Massimo Giletti's TV showL'arena, Carlo Conti announced the list of performers and songs selected to compete in the 66th Sanremo Music Festival, which included Francesca Michielin's "Nessun grado di separazione".
Michielin performed the song for the first time at the Teatro Ariston in Sanremo during the second evening of the show, on 10 February 2016.
The song placed second in the competition, behind Stadio's "Un giorno mi dirai". The band was then eligible to represent Italy in the Eurovision Song Contest 2016, but they declined, stating they would be on a previously planned tour in May 2016. Their decision led RAI to select Michielin as the Italian entry for the 61st edition of the European competition.
On 14 March 2016, a bilingual version of "Nessun grado di separazione", titled "No Degree of Separation", was announced as Michielin's entry for the contest. This version is entirely in Italian, except for the last chorus, which was adapted in English by American songwriter Norma Jean Martine; the track also has a different arrangement. Michielin performed this version for the first time on 22 March 2016, during the Web show Webnotte, streamed live by la Repubblica's website.
Since Italy is part of the "Big 5", Michielin automatically qualified to compete in the final on 14 May 2016, where she placed 16th with 124 points.