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mir-BART2 microRNA precursor family

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RNA family
mir-BART2 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-BART2
Identifiers
Symbolmir-BART2
RfamRF00364
miRBaseMI0001068
Other data
RNA typeGene; miRNA
Domain(s)Viruses
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

The mir-BART2 microRNA precursor found in Human herpesvirus 4 (Epstein–Barr virus) and Cercopithicine herpesvirus 15. mir-BART2 is expressed in all stages of infection but expression is significantly elevated in the lytic stage. In Epstein-Barr virus, mir-BART2 is found in the intronic regions of the BART (Bam HI-A region rightward transcript) gene whose function is unknown. mir-BART2 is thought to target the virally encoded DNA polymerase BALF5 for degradation. The mature sequence is excised from the 5' arm of the hairpin.

References

  1. Pfeffer S, Zavolan M, Grässer FA, Chien M, Russo JJ, Ju J, John B, Enright AJ, Marks D, Sander C, Tuschl T (April 2004). "Identification of virus-encoded microRNAs". Science. 304 (5671): 734–6. doi:10.1126/science.1096781. PMID 15118162. S2CID 25287167.

External links


miRNA precursor families
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