McN-481 - Misplaced Pages

McN-481
Names

Other names McNeil 481 NSC-42268 13M2B
Identifiers
CAS Number	3625-18-1
3D model (JSmol)	Interactive image
ChemSpider	18164
PubChem CID	19251
InChI InChI=1S/C12H18N2O3/c1-5-12(8(4)6-7(2)3)9(15)13-11(17)14-10(12)16/h6,8H,5H2,1-4H3,(H2,13,14,15,16,17)Key: VELIJARCYHAWJO-UHFFFAOYSA-N
SMILES CCC1(C(=O)NC(=O)NC1=O)C(C)C=C(C)C
Properties
Chemical formula	C₁₂H₁₈N₂O₃
Molar mass	238.287 g·mol
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	3.5 mg/kg (mice, intraperitoneal)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Infobox references

Chemical compound

McN-481 is a convulsant barbiturate. It is an unsaturated analog of diberal (DMBB).

References

Brown, DA; Quilliam, JP (October 1964). "The effects of some centrally acting drugs on ganglionic transmission in the cat". British Journal of Pharmacology and Chemotherapy. 23 (2): 241–56. doi:10.1111/j.1476-5381.1964.tb01583.x. PMC 1704089. PMID 19108183.
Jones, G. P.; Horn, E. (October 1986). "Conformations of barbiturates related to pentobarbitone. IV. Crystal structure of 5-ethyl,5-(1?,3?-dimethylbut-2?-enyl) barbituric acid". Journal of Crystallographic and Spectroscopic Research. 16 (5): 629–637. Bibcode:1986JCCry..16..629J. doi:10.1007/BF01181245.
^ Cain, C. K.; Kleis, John (February 1959). "5-Ethyl-5-(1,3-Dimethyi-2-Butenyl)Barbituric Acid, A Potent Central Nervous System Stimulant". Journal of Medicinal and Pharmaceutical Chemistry. 1 (1): 31–36. doi:10.1021/jm50002a003. PMID 13655027.
"Barbituric acid product". 26 March 1957.

v t e Convulsants
GABA receptor antagonists	Bicuculline Bicyclic phosphates (TBPS, TBPO, IPTBO) BIDN Chlorophenylsilatrane Cicutoxin Cloflubicyne Coriamyrtin Dihydropicrotoxinin DMCM EBOB Endosulfan FG-7142 Fipronil Flurothyl Gabazine Oenanthotoxin Pentylenetetrazol Phenylsilatrane Picrotoxin p-CN-TBOB p-NCS-TBOB RDX TBOB Tetramethylenedisulfotetramine Thujone Trimethylolpropane phosphite Tutin
GABA synthesis inhibitors	3-Mercaptopropionic acid 4-Deoxypyridoxine Allylglycine Crimidine Decaborane Ginkgotoxin Isoniazid Pentaborane Thiocarbohydrazide Toxopyrimidine
Glycine receptor antagonists	Coriamyrtin Dendrobine Picrotoxin Strychnine Tutin
Glutamate receptor agonists	AMPA Domoic acid Kainic acid NMDA Quisqualic acid Tetrazolylglycine
Convulsant barbiturates	CHEB Diberal (DMBB) McN-481
Other	2,2,3,3-Tetrafluoropropyl trifluoromethyl ether Bromocamphor Camphor FAZ-4 Fluoroethyl fluoroacetate MC-2973 Methionine sulfoximine Methyl fluoroacetate Nitrocyclohexane Thebaine

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