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MZF1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2FI2
Identifiers
Aliases	MZF1, MZF-1, MZF1B, ZFP98, ZNF42, ZSCAN6, myeloid zinc finger 1
External IDs	OMIM: 194550; MGI: 107457; HomoloGene: 9633; GeneCards: MZF1; OMA:MZF1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.43 Start 58,561,931 bp End 58,573,575 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A1|7 7.73 cM Start 12,776,230 bp End 12,788,691 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right uterine tube right lobe of thyroid gland right hemisphere of cerebellum Pituitary Gland left lobe of thyroid gland anterior pituitary right adrenal gland right adrenal cortex left ovary Top expressed in male urethra superior frontal gyrus primary visual cortex neural layer of retina dentate gyrus of hippocampal formation granule cell spermatid spermatocyte granulocyte tail of embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific protein homodimerization activity DNA binding protein binding nucleic acid binding metal ion binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process positive regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription by RNA polymerase II regulation of transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7593 109889 Ensembl ENSG00000099326 ENSMUSG00000030380 UniProt P28698 n/a RefSeq (mRNA) NM_001267033 NM_003422 NM_198055 NM_001290452 NM_001290453 NM_145819 NM_001382820 NM_016793 RefSeq (protein) NP_001253962 NP_003413 NP_932172 n/a Location (UCSC) Chr 19: 58.56 – 58.57 Mb Chr 7: 12.78 – 12.79 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Myeloid zinc finger 1 is a protein that in humans is encoded by the MZF1 gene.

Interactions

MZF1 has been shown to interact with SCAND1. In 2014, the laboratory of Nathan H. Lents showed that MZF-1 induces the GAPDH gene, something that must be considered when GAPDH is used as a loading control in experiments that may induce or perturb MZF-1. The same group later showed that MZF-1 induces CTGF and NOV, two members of the CCN gene family.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000099326 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000030380 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K (September 1991). "A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells". J Biol Chem. 266 (22): 14183–7. doi:10.1016/S0021-9258(18)98664-3. PMID 1860835.
6. "Entrez Gene: MZF1 myeloid zinc finger 1".
7. Sander TL, Haas AL, Peterson MJ, Morris JF (April 2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
8. Piszczatowski RT, Rafferty BJ, Rozado A, Tobak S, Lents NH (2014). "The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol". Biochem. Biophys. Res. Commun. 451 (1): 137–41. doi:10.1016/j.bbrc.2014.07.082. PMID 25065746.
9. Piszczatowski RT (2015). "Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of theCCN2/CTGFandCCN3/NOVGenes in the Hematopoietic Compartment". Journal of Cellular Physiology. 230 (11): 2634–2639. doi:10.1002/jcp.25021. PMID 25899830. S2CID 6888015.

Further reading

• Bavisotto L, Kaushansky K, Lin N, Hromas R (1991). "Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro". J. Exp. Med. 174 (5): 1097–1101. doi:10.1084/jem.174.5.1097. PMC 2119006. PMID 1719120.
• Sander TL, Haas AL, Peterson MJ, Morris JF (2000). "Identification of a novel SCAN box-related protein that interacts with MZF1B. The leucine-rich SCAN box mediates hetero- and homoprotein associations". J. Biol. Chem. 275 (17): 12857–12867. doi:10.1074/jbc.275.17.12857. PMID 10777584.
• Peterson MJ, Morris JF (2000). "Human myeloid zinc finger gene MZF produces multiple transcripts and encodes a SCAN box protein". Gene. 254 (1–2): 105–118. doi:10.1016/S0378-1119(00)00281-X. PMID 10974541.
• Takahashi K, Matsumoto C, Ra C (2005). "FHL3 negatively regulates human high-affinity IgE receptor beta-chain gene expression by acting as a transcriptional co-repressor of MZF-1". Biochem. J. 386 (Pt 1): 191–200. doi:10.1042/BJ20040775. PMC 1134781. PMID 15453830.
• Kang NY, Park YD, Choi HJ, Kim KS, Lee YC, Kim CH (2005). "Regulatory elements involved in transcription of the human NeuAcalpha2,3Galbeta1,3GalNAcalpha2,6-sialyltransferase (hST6GalNAc IV) gene". Mol. Cells. 18 (2): 157–62. doi:10.1016/S1016-8478(23)13096-2. PMID 15528990.
• Le Mée S, Fromigué O, Marie PJ (2005). "Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts". Exp. Cell Res. 302 (1): 129–142. doi:10.1016/j.yexcr.2004.08.028. PMID 15541732.
• Inoue M, Takahashi K, Niide O, Shibata M, Fukuzawa M, Ra C (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis". FEBS Lett. 579 (3): 604–608. doi:10.1016/j.febslet.2004.12.030. PMID 15670815. S2CID 30914046.
• Hsieh YH, Wu TT, Tsai JH, Huang CY, Hsieh YS, Liu JY (2006). "PKCalpha expression regulated by Elk-1 and MZF-1 in human HCC cells". Biochem. Biophys. Res. Commun. 339 (1): 217–225. doi:10.1016/j.bbrc.2005.11.015. PMID 16297876.
• Peterson FC, Hayes PL, Waltner JK, Heisner AK, Jensen DR, Sander TL, Volkman BF (2006). "Structure of the SCAN domain from the tumor suppressor protein MZF1". J. Mol. Biol. 363 (1): 137–147. doi:10.1016/j.jmb.2006.07.063. PMC 1941711. PMID 16950398.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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