Lleras may refer to:
- Alberto Lleras Camargo (1906–1990), important Colombian diplomat and political figure
- Carlos Lleras Restrepo (1908–1994), important Colombian lawyer and political figure
- Cecilia de la Fuente de Lleras (1919–2004), First Lady of Colombia under (1966-1970)
- Germán Vargas Lleras (born 1962), Colombian politician and lawyer
- Puerto Lleras, town and municipality in the Meta Department, Colombia
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