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This list of University of Puerto Rico people includes alumni, faculty, and presidents of University of Puerto Rico systemwide.
Jacob Lozada, colonel, U.S. Army, assistant secretary of veterans affairs
José Antonio Muñiz, lieutenant colonel, U.S. Air Force; together with then-Colonels Alberto A. Nido and Mihiel Gilormini he founded the Puerto Rico Air National Guard. In 1963, the Air National Guard Base, at the San Juan International airport in Puerto Rico, was renamed "Muñiz Air National Guard Base" in his honor.
Orlando Figueroa, director of the Mars Exploration Program in NASA
Enectalí Figueroa-Feliciano, astrophysicist and researcher with the NASA who pioneered the development position-sensitive detectors
Adolfo Figueroa-Viñas, Ph.D., first Puerto Rican astrophysicist at the National Aeronautics and Space Administration (NASA) and is an expert in solar and space plasma physics at the Heliophysics Science Division
Joxel García, Puerto Rican physician and former four-star admiral in the U.S. Public Health Service Commissioned Corps
Sixto Gonzalez, first Puerto Rican to be named director of the Arecibo Observatory, the world's largest single-dish radio telescope
Olga D. González-Sanabria, Puerto Rican scientist and inventor and the highest-ranking Hispanic at NASA Glenn Research Center
Hans Hertell, former United States Ambassador to the Dominican Republic
Jesús T. Piñero, first native Puerto Rican to be appointed governor of Puerto Rico by the Government of the United States
Juan Mari Brás, advocate for Puerto Rican independence from the United States who founded the Puerto Rican Socialist Party (PSP).
Wilfredo Mattos Cintrón, teacher at the university, advocate of Puerto Rican independence who was, along with Mari Brás, a member of the PSP.
Kenneth McClintock, current Secretary of State of Puerto Rico, fulfilling the role of lieutenant governor (first-in-line of succession) in the U.S. territory.
Rexford Tugwell, served as the last appointed American Governor of Puerto Rico from 1941 to 1946, also served as chancellor of the University of Puerto Rico