L-saccharopine oxidase

L-saccharopine oxidase (EC 1.5.3.18, FAP2) is an enzyme with systematic name L-saccharopine:oxygen oxidoreductase (L-glutamate forming). This enzyme catalyses the following chemical reaction

N-(L-1,3-dicarboxypropyl)-L-lysine + H₂O + O₂

\rightleftharpoons

(S)-2-amino-6-oxohexanoate + L-glutamate + H₂O₂

The enzyme is involved in pipecolic acid biosynthesis.

References

Yoshida N, Akazawa S, Katsuragi T, Tani Y (2004). "Characterization of two fructosyl-amino acid oxidase homologs of Schizosaccharomyces pombe". Journal of Bioscience and Bioengineering. 97 (4): 278–80. doi:10.1016/S1389-1723(04)70204-2. PMID 16233628.
Wickwire BM, Wagner C, Broquist HP (September 1990). "Pipecolic acid biosynthesis in Rhizoctonia leguminicola. II. Saccharopine oxidase: a unique flavin enzyme involved in pipecolic acid biosynthesis". The Journal of Biological Chemistry. 265 (25): 14748–53. PMID 2394693.

L-saccharopine+oxidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Oxidoreductases: CH-NH (EC 1.5)
1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase
1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase
1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase
1.5.99	Sarcosine dehydrogenase Cytokinin dehydrogenase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)