KCNT2

Protein-coding gene in the species Homo sapiens

KCNT2

Identifiers

KCNT2, KCa4.2, SLICK, SLO2.1, potassium sodium-activated channel subfamily T member 2, EIEE57, DEE57

External IDs

OMIM: 610044; MGI: 3036273; HomoloGene: 16121; GeneCards: KCNT2; OMA:KCNT2 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q31.3	Start	196,225,779 bp
Band	1q31.3	End	196,609,225 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 F	Start	140,173,896 bp
Band	1\|1 F	End	140,539,805 bp

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

parietal pleura

endothelial cell

cartilage tissue

Brodmann area 23

Brodmann area 46

middle temporal gyrus

germinal epithelium

Achilles tendon

visceral pleura

cardiac muscle tissue of right atrium

Top expressed in

aortic valve

prefrontal cortex

vas deferens

primary motor cortex

ascending aorta

medial dorsal nucleus

lateral septal nucleus

cingulate gyrus

dentate gyrus

subdivision of hippocampus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	voltage-gated potassium channel activity ATP binding nucleotide binding potassium channel activity calcium-activated potassium channel activity intracellular sodium activated potassium channel activity outward rectifier potassium channel activity chloride-activated potassium channel activity
Cellular component	voltage-gated potassium channel complex integral component of membrane plasma membrane membrane
Biological process	potassium ion transmembrane transport potassium ion transport ion transport regulation of membrane potential potassium ion export across plasma membrane
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


343450


240776

Ensembl


ENSG00000162687


ENSMUSG00000052726

UniProt


Q6UVM3


n/a

RefSeq (mRNA)


NM_001287819 NM_001287820 NM_198503


NM_001081027

RefSeq (protein)


NP_001274748 NP_001274749 NP_940905


n/a

Location (UCSC)

Chr 1: 196.23 – 196.61 Mb

Chr 1: 140.17 – 140.54 Mb

PubMed search

Wikidata

View/Edit Human

View/Edit Mouse

Potassium channel subfamily T, member 2, also known as KCNT2 is a human gene that encodes the K_Na protein. KCNT2, also known as the Slick channel (sequence like an intermediate calcium channel) is an outwardly rectifying potassium channel activated by internal raises in sodium or chloride ions.

References

^ GRCh38: Ensembl release 89: ENSG00000162687 – Ensembl, May 2017
^ GRCm38: Ensembl release 89: ENSMUSG00000052726 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

Bhattacharjee A, Joiner WJ, Wu M, et al. (2003). "Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP". J. Neurosci. 23 (37): 11681–91. doi:10.1523/JNEUROSCI.23-37-11681.2003. PMC 6740956. PMID 14684870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Santi CM, Ferreira G, Yang B, et al. (2006). "Opposite regulation of Slick and Slack K+ channels by neuromodulators". J. Neurosci. 26 (19): 5059–68. doi:10.1523/JNEUROSCI.3372-05.2006. PMC 6674240. PMID 16687497.
Wei AD, Gutman GA, Aldrich R, et al. (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol. Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103. S2CID 8290401.

Membrane transport protein: ion channels (TC 1A)

Ca: Calcium channel

Ligand-gated

Inositol trisphosphate receptor
- 1
- 2
- 3
Ryanodine receptor
- 1
- 2
- 3

Voltage-gated

L-type/Ca_vα
- 1.1
- 1.2
- 1.3
- 1.4
N-type/Ca_vα2.2
P-type/Ca_vα
- 2.1
Q-type/Ca_vα2.1
R-type/Ca_vα2.3
T-type/Ca_vα
- 3.1
- 3.2
- 3.3

α₂δ-subunits
- 1
- 2
β-subunits
- β1
- β2
- β3
- β4
γ-subunits
- γ1
- γ2
- γ3
- γ4

Cation channels of sperm
- 1
- 2
- 3
- 4
Two-pore channel
- 1
- 2

Na: Sodium channel

Constitutively active	Epithelial sodium channel α β γ δ
Proton-gated	Amiloride-sensitive cation channel 1 2 3 4
Voltage-gated	Na_vα 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 7A Na_vβ 1 2 3 4

K: Potassium channel

Calcium-activated	BK channel α1 β1 β2 β3 β4 SK channel SK1 SK2 SK3 IK channel IK1 K_Ca 1.1 2.1 2.2 2.3 3.1 4.1 4.2 5.1
Inward-rectifier	K_ATP K_ir 1.1 2.1 2.2 2.3 2.4 2.6 GIRK/K_ir 3.1 3.2 3.3 3.4 K_ir 4.1 4.2 5.1 6.1 6.2 7.1
Tandem pore domain	K2P 1 2 3 4 5 6 7 9 10 12 13 15 16 17 18
Voltage-gated	K_vα1-6 1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 2.1 2.2 3.1 3.2 3.3 3.4 4.1 4.2 4.3 5.1 6.1 6.2 6.3 6.4 K_vα7-12 7.1 7.2 7.3 7.4 7.5 8.1 8.2 9.1 9.2 9.3 10.1 10.2 11.1/hERG 11.2 11.3 12.1 12.2 12.3 K_vβ 1 2 3 KCNIP 1 2 3 4 minK/ISK minK/ISK-like MiRP 1 2 3 Shaker (gene)

Miscellaneous

Cl: Chloride channel	Calcium-activated chloride channels Anoctamin ANO1 Bestrophin 1 2 Chloride Channel Accessory 1 2 3 4 CFTR CLCN 1 2 3 4 5 6 7 KA KB CLIC 1 2 3 4 5 6 L1 CLNS 1A 1B
H: Proton channel	HVCN1
M: CNG cation channel	α 1 2 3 4 β 1 2 3 HCN FC 1 2 3 4
M: TRP cation channel	TRPA (1) TRPC 1 2 3 4 4AP 5 6 7 TRPM 1 2 3 4 5 6 7 8 TRPML 1 2 3 TRPN TRPP 1 2 TRPV 1 2 3 4 5 6
H₂O (+ solutes): Porin	Aquaporin 0 1 2 3 4 5 6 7 8 9 Voltage-dependent anion channel 1 2 3 General bacterial porin family
Cytoplasm: Gap junction	Connexin A GJA1 GJA3 GJA4 GJA5 GJA8 GJA9 GJA10 B GJB1 GJB2 GJB3 GJB4 GJB5 GJB6 GJB7 C GJC1 GJC2 GJC3 D GJD2 GJD3 GJD4 Innexin

By gating mechanism

Ion channel class	Ligand-gated Light-gated Voltage-gated Stretch-activated

see also disorders

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References

Further reading