Infectious pancreatic necrosis birnavirus Vp4 peptidase

Infectious pancreatic necrosis birnavirus Vp4 peptidase (EC 3.4.21.115, infectious pancreatic necrosis virus protease, IPNV Vp4 protease, IPNV Vp4 peptidase, NS protease, NS-associated protease, Vp4 protease) is an enzyme. This enzyme catalyses the following chemical reaction

Cleaves the (Ser/Thr)-Xaa-Ala-(Ser/Ala)-Gly motif in the polyprotein NH₂-pVP2-VP4-VP3-COOH of infectious pancreatic necrosis virus at the pVP2-VP4 and VP4-VP3 junctions

Infectious pancreatic necrosis virus is a birnavirus that causes an acute, contagious disease in young salmonid fish.

References

Manning DS, Leong JC (November 1990). "Expression in Escherichia coli of the large genomic segment of infectious pancreatic necrosis virus". Virology. 179 (1): 16–25. doi:10.1016/0042-6822(90)90268-v. PMID 2219718.
Petit S, Lejal N, Huet JC, Delmas B (March 2000). "Active residues and viral substrate cleavage sites of the protease of the birnavirus infectious pancreatic necrosis virus". Journal of Virology. 74 (5): 2057–66. doi:10.1128/jvi.74.5.2057-2066.2000. PMC 111686. PMID 10666235.
Dobos, P. (1995). "The molecular biology of infectious pancreatic necrosis virus (IPNV)". Annu. Rev. Fish Dis. 5: 25–54. doi:10.1016/0959-8030(95)00003-8.

External links

Infectious+pancreatic+necrosis+birnavirus+Vp4+peptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

v t e Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes	Enteropeptidase Trypsin Chymotrypsin Elastase Neutrophil Pancreatic
Coagulation	factors: Thrombin Factor VIIa Factor IXa Factor Xa Factor XIa Factor XIIa Kallikrein PSA KLK1 KLK2 KLK3 KLK4 KLK5 KLK6 KLK7 KLK8 KLK9 KLK10 KLK11 KLK12 KLK13 KLK14 KLK15 fibrinolysis: Plasmin Plasminogen activator Tissue plasminogen activator Urinary plasminogen activator
Complement system	Factor B Factor D Factor I MASP MASP1 MASP2 C3-convertase
Other immune system	Chymase Granzyme Tryptase Proteinase 3/Myeloblastin
Venombin	Ancrod Batroxobin
Other	Acrosin Prolyl endopeptidase Pronase Proprotein convertases 1 2 Prostasin Reelin Subtilisin/Furin/S1P4 Sedolisin/TPP1 Streptokinase Cathepsin A G

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Portal:

Biology

Category:

EC 3.4.21