Guastavino is a surname. Notable people with the surname include:
- Rafael Guastavino (1842–1908), Spanish architect and builder
- Jean-Marie Guastavino (1886-1960), French politician
- Carlos Guastavino (1912-2000), Argentine composer
- Pedro Guastavino (born 1954), Argentine politician
- Diego Guastavino (born 1984), Uruguayan football player
- Vera Guastavino (born 1957), Belgian Physician
See also
- Guastavino tile, patented by Rafael Guastavino in 1885
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