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Group II pyridoxal-dependent decarboxylases

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Class of enzymes
It has been suggested that this article be merged with Group I pyridoxal-dependent decarboxylases. (Discuss) Proposed since January 2025.
Protein domain
Pyridoxal-dependent decarboxylase conserved domain
crystal structure of the murine class ii allele i-a(g7) complexed with the glutamic acid decarboxylase (gad65) peptide 207-220
Identifiers
SymbolPyridoxal_deC
PfamPF00282
Pfam clanCL0061
InterProIPR002129
PROSITEPDOC00329
SCOP21js3 / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

In molecular biology, group II pyridoxal-dependent decarboxylases are a family of enzymes including aromatic-L-amino-acid decarboxylase (L-dopa decarboxylase or tryptophan decarboxylase) EC 4.1.1.28 that catalyse the decarboxylation of tryptophan to tryptamine, tyrosine decarboxylase EC 4.1.1.25 that converts tyrosine into tyramine and histidine decarboxylase EC 4.1.1.22 that catalyses the decarboxylation of histidine to histamine.

Pyridoxal-5'-phosphate-dependent amino acid decarboxylases can be divided into four groups based on amino acid sequence: group II includes glutamate, histidine, tyrosine, and aromatic-L-amino-acid decarboxylases.

See also

References

  1. Ishii S, Mizuguchi H, Nishino J, Hayashi H, Kagamiyama H (August 1996). "Functionally important residues of aromatic L-amino acid decarboxylase probed by sequence alignment and site-directed mutagenesis". J. Biochem. 120 (2): 369–76. doi:10.1093/oxfordjournals.jbchem.a021422. PMID 8889823.
  2. Joseph DR, Sullivan PM, Wang YM, Kozak C, Fenstermacher DA, Behrendsen ME, Zahnow CA (January 1990). "Characterization and expression of the complementary DNA encoding rat histidine decarboxylase". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 733–7. Bibcode:1990PNAS...87..733J. doi:10.1073/pnas.87.2.733. PMC 53340. PMID 2300558.
  3. Sandmeier E, Hale TI, Christen P (May 1994). "Multiple evolutionary origin of pyridoxal-5'-phosphate-dependent amino acid decarboxylases". Eur. J. Biochem. 221 (3): 997–1002. doi:10.1111/j.1432-1033.1994.tb18816.x. PMID 8181483.
This article incorporates text from the public domain Pfam and InterPro: IPR002129 Category:
Group II pyridoxal-dependent decarboxylases Add topic