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ADGRE1
Identifiers
Aliases	ADGRE1, TM7LN3, EMR1, adhesion G protein-coupled receptor E1
External IDs	OMIM: 600493; MGI: 106912; HomoloGene: 1493; GeneCards: ADGRE1; OMA:ADGRE1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3-p13.2 Start 6,887,566 bp End 6,940,459 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 D|17 29.8 cM Start 57,665,691 bp End 57,790,527 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte blood granulocyte testicle spleen bone marrow appendix right lung bone marrow cells palpebral conjunctiva Top expressed in stroma of bone marrow muscle layer of urethra calvaria granulocyte mesenteric lymph nodes lamina propria of urethra spleen right ventricle tibiofemoral joint ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane cell periphery intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway cell adhesion adaptive immune response signal transduction immune system process adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2015 13733 Ensembl ENSG00000174837 ENSMUSG00000004730 UniProt Q14246 Q61549 RefSeq (mRNA) NM_001256252 NM_001256253 NM_001256254 NM_001256255 NM_001974 NM_010130 NM_001355722 NM_001355723 RefSeq (protein) NP_001243181 NP_001243182 NP_001243183 NP_001243184 NP_001965 NP_034260 NP_001342651 NP_001342652 Location (UCSC) Chr 19: 6.89 – 6.94 Mb Chr 17: 57.67 – 57.79 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

EGF-like module-containing mucin-like hormone receptor-like 1 also known as F4/80 is a protein encoded by the ADGRE1 gene.

EMR1 is a member of the adhesion GPCR family characterized by an extended extracellular region containing EGF-like domains. EMR1 is predominantly expressed on the surface of macrophages and plays a significant role in immune response modulation and inflammation. Its expression has been linked to various inflammatory diseases.

Structure

Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

The N-terminal fragment (NTF) of EMR1 contains 4-6 Epidermal Growth Factor-like (EGF-like) domains in human and 4-7 EGF-like domains in the mouse.

Tissue distribution

EMR1 expression in human is restricted to eosinophils and is a specific marker for these cells. The murine homolog of EMR1, F4/80, is a well-known and widely used marker of murine macrophage populations.

Function

F4/80 is not necessary for the development of tissue macrophages but is required for the induction of efferent CD8 regulatory T cells needed for peripheral tolerance.

Clinical significance

EMR1 can serve as a therapeutic target for depletion of these cells in eosinophilic disorders by using afucosylated antibodies.

See also

• EGF module-containing mucin-like hormone receptor

References

1. ^ GRCh38: Ensembl release 89: ENSG00000174837 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000004730 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baud V, Chissoe SL, Viegas-Péquignot E, Diriong S, N'Guyen VC, Roe BA, et al. (March 1995). "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics. 26 (2): 334–344. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
6. McKnight AJ, Gordon S (March 1998). "The EGF-TM7 family: unusual structures at the leukocyte surface". Journal of Leukocyte Biology. 63 (3): 271–280. doi:10.1002/jlb.63.3.271. PMID 9500513. S2CID 6497890.
7. "Entrez Gene: EMR1 egf-like module containing, mucin-like, hormone receptor-like 1".
8. Leenen PJ, de Bruijn MF, Voerman JS, Campbell PA, van Ewijk W (September 1994). "Markers of mouse macrophage development detected by monoclonal antibodies". Journal of Immunological Methods. 174 (1–2): 5–19. doi:10.1016/0022-1759(94)90005-1. hdl:1765/71089. PMID 8083537.
9. Hamann J, Aust G, Araç D, Engel FB, Formstone C, Fredriksson R, et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews. 67 (2): 338–367. doi:10.1124/pr.114.009647. PMC 4394687. PMID 25713288.
10. Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4.
11. Langenhan T, Aust G, Hamann J (May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage". Science Signaling. 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. S2CID 6958640.
12. Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, et al. (March 2012). "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal. 31 (6): 1364–1378. doi:10.1038/emboj.2012.26. PMC 3321182. PMID 22333914.
13. Gordon S, Hamann J, Lin HH, Stacey M (September 2011). "F4/80 and the related adhesion-GPCRs". European Journal of Immunology. 41 (9): 2472–2476. doi:10.1002/eji.201141715. PMID 21952799.
14. Hamann J, Koning N, Pouwels W, Ulfman LH, van Eijk M, Stacey M, et al. (October 2007). "EMR1, the human homolog of F4/80, is an eosinophil-specific receptor". European Journal of Immunology. 37 (10): 2797–2802. doi:10.1002/eji.200737553. PMID 17823986.
15. Austyn JM, Gordon S (October 1981). "F4/80, a monoclonal antibody directed specifically against the mouse macrophage". European Journal of Immunology. 11 (10): 805–815. doi:10.1002/eji.1830111013. PMID 7308288. S2CID 8426640.
16. Lin HH, Faunce DE, Stacey M, Terajewicz A, Nakamura T, Zhang-Hoover J, et al. (May 2005). "The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance". The Journal of Experimental Medicine. 201 (10): 1615–1625. doi:10.1084/jem.20042307. PMC 2212925. PMID 15883173.
17. Legrand F, Tomasevic N, Simakova O, Lee CC, Wang Z, Raffeld M, et al. (May 2014). "The eosinophil surface receptor epidermal growth factor-like module containing mucin-like hormone receptor 1 (EMR1): a novel therapeutic target for eosinophilic disorders". The Journal of Allergy and Clinical Immunology. 133 (5): 1439–47, 1447.e1–8. doi:10.1016/j.jaci.2013.11.041. PMC 4113341. PMID 24530099.

External links

• GPCR consortium

• Genes on human chromosome 19
• G protein-coupled receptors