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Dicarboxylate—CoA ligase

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Dicarboxylate—CoA ligase
Identifiers
EC no.6.2.1.23
CAS no.99332-77-1
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In enzymology, a dicarboxylate—CoA ligase (EC 6.2.1.23) is an enzyme that catalyzes the chemical reaction

ATP + an alphaomega-dicarboxylic acid + CoA {\displaystyle \rightleftharpoons } AMP + diphosphate + an omega-carboxyacyl-CoA

The 3 substrates of this enzyme are ATP, alphaomega-dicarboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and omega-carboxyacyl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is omega-dicarboxylate:CoA ligase (AMP-forming). Other names in common use include carboxylyl-CoA synthetase, and dicarboxylyl-CoA synthetase.

References

Enzymes: CO CS and CN ligases (EC 6.1-6.3)
6.1: Carbon-Oxygen
6.2: Carbon-Sulfur
6.3: Carbon-Nitrogen
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