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Delta12-fatty-acid desaturase (EC 1.14.19.6, Delta12 fatty acid desaturase, Delta12(omega6)-desaturase, oleoyl-CoA Delta12 desaturase, Delta12 desaturase, Delta12-desaturase) is an enzyme with systematic name acyl-CoA,hydrogen donor:oxygen Delta12-oxidoreductase. This enzyme catalyses the following chemical reaction

acyl-CoA + reduced acceptor + O₂ ${\displaystyle \rightleftharpoons }$ Delta12-acyl-CoA + acceptor + 2 H₂O

In the yeast Lipomyces starkeyi and in the American cockroach, this microsomal enzyme converts oleoyl-CoA into linoleoyl-CoA.

References

1. Borgeson CE, de Renobales M, Blomquist GJ (November 1990). "Characterization of the delta 12 desaturase in the American cockroach, Periplaneta americana: the nature of the substrate". Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1047 (2): 135–40. doi:10.1016/0005-2760(90)90039-z. PMID 2248971.
2. Jurenka RA (June 1997). "Biosynthetic pathway for producing the sex pheromone component (Z,E)-9,12-tetradecadienyl acetate in moths involves a delta 12 desaturase". Cellular and Molecular Life Sciences. 53 (6): 501–5. doi:10.1007/s000180050062. PMC 11147184. PMID 9230926. S2CID 20152524.
3. Lomascolo A, Dubreucq E, Galzy P (March 1996). "Study of the delta 12-desaturase system of Lipomyces starkeyi". Lipids. 31 (3): 253–9. doi:10.1007/bf02529871. PMID 8900454. S2CID 27459395.
4. Tocher DR, Leaver MJ, Hodgson PA (1998). "Recent advances in the biochemistry and molecular biology of fatty acyl desaturases". Progress in Lipid Research. 37 (2–3): 73–117. doi:10.1016/s0163-7827(98)00005-8. PMID 9829122.

External links

• Delta12-fatty-acid+desaturase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

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