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RPL35
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5AJ0, 4V5Z, 4UJD, 4D67, 4D5Y, 4UJE, 4UJC
Identifiers
Aliases	RPL35, L35, ribosomal protein L35, DBA19
External IDs	OMIM: 618315; MGI: 1913739; HomoloGene: 31432; GeneCards: RPL35; OMA:RPL35 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q33.3 Start 124,857,880 bp End 124,861,981 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 38,891,592 bp End 38,895,636 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg skin of thigh anterior pituitary right testis olfactory zone of nasal mucosa left testis left ovary right uterine tube skin of hip Top expressed in urinary bladder ovary genital tubercle embryo neural tube embryo adrenal gland placenta white adipose tissue bone marrow More reference expression data BioGPS n/a
Gene ontology Molecular function mRNA binding RNA binding structural constituent of ribosome Cellular component cytosol ribosome membrane intracellular anatomical structure nucleolus cytosolic large ribosomal subunit Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay rRNA processing protein biosynthesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11224 66489 Ensembl ENSG00000136942 ENSMUSG00000062997 UniProt P42766 Q6ZWV7 RefSeq (mRNA) NM_007209 NM_025592 RefSeq (protein) NP_009140 NP_079868 Location (UCSC) Chr 9: 124.86 – 124.86 Mb Chr 2: 38.89 – 38.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

60S ribosomal protein L35 is a protein that in humans is encoded by the RPL35 gene.

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

References

1. ^ GRCh38: Ensembl release 89: ENSG00000136942 – Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000062997 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Uechi T, Tanaka T, Kenmochi N (Jun 2001). "A complete map of the human ribosomal protein genes: assignment of 80 genes to the cytogenetic map and implications for human disorders". Genomics. 72 (3): 223–30. doi:10.1006/geno.2000.6470. PMID 11401437.
6. ^ "Entrez Gene: RPL35 ribosomal protein L35".

External links

• Human RPL35 genome location and RPL35 gene details page in the UCSC Genome Browser.
• Overview of all the structural information available in the PDB for UniProt: P42766 (Human 60S ribosomal protein L35) at the PDBe-KB.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Ou JH, Yen TS, Wang YF, et al. (1988). "Cloning and characterization of a human ribosomal protein gene with enhanced expression in fetal and neoplastic cells". Nucleic Acids Res. 15 (21): 8919–34. doi:10.1093/nar/15.21.8919. PMC 306413. PMID 2891103.
• Kato S, Sekine S, Oh SW, et al. (1995). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene. 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Mammalian Gene Collection Program Team; Strausberg, R. L.; Feingold, E. A.; Grouse, L. H.; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Odintsova TI, Müller EC, Ivanov AV, et al. (2004). "Characterization and analysis of posttranslational modifications of the human large cytoplasmic ribosomal subunit proteins by mass spectrometry and Edman sequencing". J. Protein Chem. 22 (3): 249–58. doi:10.1023/A:1025068419698. PMID 12962325. S2CID 10710245.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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