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In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD + H₂O ${\displaystyle \rightleftharpoons }$ a 2-oxo acid + NADH + H

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H.

This enzyme participates in pyruvate metabolism.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include:

• alpha-ketoaldehyde dehydrogenase
• methylglyoxal dehydrogenase
• NAD+-linked alpha-ketoaldehyde dehydrogenase
• 2-ketoaldehyde dehydrogenase
• NAD+-dependent alpha-ketoaldehyde dehydrogenase
• 2-oxoaldehyde dehydrogenase (NAD+)

See also

• 2-oxoaldehyde dehydrogenase (NADP+)

References

• Monder C (1967). "Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 242 (20): 4603–9. PMID 4383524.
• Ray M, Ray S (1982). "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase". J. Biol. Chem. 257 (18): 10571–4. PMID 7107626.
• Ray S, Ray M (1982). "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 257 (18): 10566–70. PMID 7107625.

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