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The 1910 Iowa Hawkeyes football team represented the University of Iowa as a member of the Missouri Valley Conference (MVC) and the Western Conference during the 1910 college football season. Led by first-year head coach Jesse Hawley, the Hawkeyes compiled an overall record of 5–2 with a mark of 1–1 in MVC play, placing fourth in the MVC. Iowa was 3–1 against Western Conference opponents, finishing second in that conference.