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16S rRNA pseudouridine synthase (EC 5.4.99.19, 16S RNA pseudouridine synthase, 16S PsiI synthase, 16S RNA Psi synthase, RNA pseudouridine synthase RsuA, RsuA, 16S RNA pseudouridine 516 synthase) is an enzyme with systematic name 16S rRNA-uridine uracil mutase. This enzyme catalyses the following chemical reaction

16S rRNA uridine ${\displaystyle \rightleftharpoons }$ 16S rRNA pseudouridine

The enzyme is specific for uridine in 16S rRNA.

References

1. Wrzesinski J, Bakin A, Nurse K, Lane BG, Ofengand J (July 1995). "Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli". Biochemistry. 34 (27): 8904–13. doi:10.1021/bi00027a043. PMID 7612632.
2. Conrad J, Niu L, Rudd K, Lane BG, Ofengand J (June 1999). "16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases". RNA. 5 (6): 751–63. doi:10.1017/s1355838299990167. PMC 1369802. PMID 10376875.
3. Sivaraman J, Sauvé V, Larocque R, Stura EA, Schrag JD, Cygler M, Matte A (May 2002). "Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP". Nature Structural Biology. 9 (5): 353–8. doi:10.1038/nsb788. PMID 11953756. S2CID 22037795.

External links

• 16S+rRNA+pseudouridine516+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

• Biology

• EC 5.4.99