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Oxyclozanide

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Oxyclozanide
Names
IUPAC name 2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.017.186 Edit this at Wikidata
KEGG
PubChem CID
UNII
CompTox Dashboard (EPA)
InChI
  • InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)Key: JYWIYHUXVMAGLG-UHFFFAOYSA-N
  • InChI=1/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)Key: JYWIYHUXVMAGLG-UHFFFAOYAW
SMILES
  • C1=C(C=C(C(=C1Cl)O)NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)Cl
Properties
Chemical formula C13H6Cl5NO3
Molar mass 401.46 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). ☒N verify (what is  ?) Infobox references
Chemical compound

Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of Fascioliasis in ruminants mainly domestic animals like Cattle, Sheep and Goats. It mainly acts by uncoupling of Oxidative phosphorylation in flukes. Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against Methicillin-resistant Staphylococcus aureus (MRSA)".

References

  1. Oxyclozanide at PubChem
  2. Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus at PLOS


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