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This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Butyrophenone" – news · newspapers · books · scholar · JSTOR (December 2009) (Learn how and when to remove this message)

Butyrophenone

Names
IUPAC name 1-phenylbutan-1-one
Identifiers
CAS Number	495-40-9
3D model (JSmol)	Interactive image Interactive image
ChEMBL	ChEMBL193524
ChemSpider	9893
ECHA InfoCard	100.007.091
PubChem CID	10315
CompTox Dashboard (EPA)	DTXSID3047059
InChI InChI=1S/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3Key: FFSAXUULYPJSKH-UHFFFAOYSA-N InChI=1/C10H12O/c1-2-6-10(11)9-7-4-3-5-8-9/h3-5,7-8H,2,6H2,1H3Key: FFSAXUULYPJSKH-UHFFFAOYAC
SMILES O=C(c1ccccc1)CCC CCCC(=O)c1ccccc1
Properties
Chemical formula	C10H12O
Molar mass	148.20 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa). Y verify (what is  ?) Infobox references

Butyrophenone is a chemical compound (with a ketone functional group); some of its derivatives (called commonly butyrophenones) are used to treat various psychiatric disorders such as schizophrenia, as well as acting as antiemetics.

Butyrophenones are a class of pharmaceutical drugs derived from butyrophenone.

Examples include:

• Haloperidol, the most widely used classical antipsychotic drug in this class
• Droperidol, often used for neuroleptanalgesic anesthesia and sedation in intensive-care treatment
• Benperidol, the most potent commonly-used antipsychotic ( 200 times more potent than chlorpromazine)
• Triperidol, a highly-potent antipsychotic (100 times more potent than chlorpromazine)
• Melperone, a weakly-potent antipsychotic, in Europe commonly used for treatment of insomnia, confusional states, psychomotor agitation, and delirium, in particular, in geriatric patients
• Lenperone
• Domperidone, a dopamine-antagonist antiemetic, derived further from butyrophenone (not being a butyrophenone itself).

The atypical antipsychotic risperidone, although not a butyrophenone, was developed with the structures of benperidol and lenperone as a basis.

References

This article does not cite any sources. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Butyrophenone" – news · newspapers · books · scholar · JSTOR (January 2010) (Learn how and when to remove this message)

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