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Scrambler therapy (sometimes Calmare scramber therapy or Calmare therapy) involves the use of electronic stimulation on the skin with the goal of substituting pain information for non-pain information.
It was invented by Giuseppe Marineo at the University of Rome Tor Vergata. The device used is a Calmare MC5-A device. It has been FDA-cleared 510(k)-cleared and European CE mark-certified.
Treatment is adminstered as follows:
- mixed or neuropathic pain - 10/12 consecutive treatments of 30 or 45 minutes; once a day for five days a week.
- cancer pain - initial treatment program consisting of 10/12 consecutive treatments of 45 minutes, once a day, and every time the pain reappears. Analgesia on patient request.
Research on the efficacy of scrambler therapy has had mixed results. Uncontrolled studies have found some benefit for treating chemotherapy-induced peripheral neuropathy. One randomized controlled study found that scrambler therapy was more effective than guideline-based drug management for treating neuropathic pain. However, a randomized, double-blind study found no benefit over a placebo therapy.ref name="pachman2014" />
References
- ^ Pachman, D. R., Watson, J. C., & Loprinzi, C. L. (2014). "Therapeutic Strategies for Cancer Treatment Related Peripheral Neuropathies". Current Treatment Options in Oncology. 15 (4): 577.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - Anson P National Pain Report 9 April 2014 Inventor of Calmare Scrambler Tries to Block Sales
- http://calmaretherapynj.com/what-is-calmare
- Calmare - doctor Q&A
- ^ Rivera, E., & Cianfrocca, M. (2015). "Overview of neuropathy associated with taxanes for the treatment of metastatic breast cancer". Cancer Chemotherapy and Pharmacology. 75 (4): 659–670.
{{cite journal}}: CS1 maint: multiple names: authors list (link)