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Chris P. Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Professor of Genomics at the University of Oxford and group leader in the MRC Functional Genomics Unit, and is affiliated with the Oxford Centre for Gene Function, and Oxford's Department of Physiology, Anatomy and Genetics. After receiving his B.A. and M.Sc. in physics from Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his doctorate in biophysics in 1991.

Prof. Ponting contributed to the Human Genome Project, and did much of the sequence comparison for the mouse, rat, chicken, dog, opossum, and platypus Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure and the genetics of numerous conditions including asthma, obesity, Alzheimer's disease, retinitis pigmentosa, muscular dystrophies, and Aicardi-Goutières syndrome.

References

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4. Amos, Jonathan (March 31, 2004). "Rat's 'life code' read by science". BBC News. Retrieved December 19, 2008.
5. "Chicken gives up genetic secrets". BBC News. December 9, 2004. Retrieved December 19, 2008.
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7. Mikkelsen, Ts; Wakefield, Mj; Aken, B; Amemiya, Ct; Chang, Jl; Duke, S; Garber, M; Gentles, Aj; Goodstadt, L; Heger, A; Jurka, J; Kamal, M; Mauceli, E; Searle, Sm; Sharpe, T; Baker, Ml; Batzer, Ma; Benos, Pv; Belov, K; Clamp, M; Cook, A; Cuff, J; Das, R; Davidow, L; Deakin, Je; Fazzari, Mj; Glass, Jl; Grabherr, M; Greally, Jm; Gu, W; Hore, Ta; Huttley, Ga; Kleber, M; Jirtle, Rl; Koina, E; Lee, Jt; Mahony, S; Marra, Ma; Miller, Rd; Nicholls, Rd; Oda, M; Papenfuss, At; Parra, Ze; Pollock, Dd; Ray, Da; Schein, Je; Speed, Tp; Thompson, K; Vandeberg, Jl; Wade, Cm; Walker, Ja; Waters, Pd; Webber, C; Weidman, Jr; Xie, X; Zody, Mc; Broad, Institute, Genome, Sequencing, Platform; Broad, Institute, Whole, Genome, Assembly, Team; Graves, Ja; Ponting, Cp; Breen, M; Samollow, Pb; Lander, Es; Lindblad-Toh, K (2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature. 447 (7141): 167–77. doi:10.1038/nature05805. ISSN 0028-0836. PMID 17495919. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
8. Briggs, Helen (May 7, 2008). "Platypus genetic code unravelled". BBC News. Retrieved December 19, 2008.
9. Rea, S; Eisenhaber, F; O'carroll, D; Strahl, Bd; Sun, Zw; Schmid, M; Opravil, S; Mechtler, K; Ponting, Cp; Allis, Cd; Jenuwein, T (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–9. doi:10.1038/35020506. ISSN 0028-0836. PMID 10949293. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
10. Zhang, Y; Leaves, Ni; Anderson, Gg; Ponting, Cp; Broxholme, J; Holt, R; Edser, P; Bhattacharyya, S; Dunham, A; Adcock, Im; Pulleyn, L; Barnes, Pj; Harper, Ji; Abecasis, G; Cardon, L; White, M; Burton, J; Matthews, L; Mott, R; Ross, M; Cox, R; Moffatt, Mf; Cookson, Wo (2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature genetics. 34 (2): 181–6. doi:10.1038/ng1166. ISSN 1061-4036. PMID 12754510. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
11. Gerken, T; Girard, Ca; Tung, Yc; Webby, Cj; Saudek, V; Hewitson, Ks; Yeo, Gs; Mcdonough, Ma; Cunliffe, S; Mcneill, La; Galvanovskis, J; Rorsman, P; Robins, P; Prieur, X; Coll, Ap; Ma, M; Jovanovic, Z; Farooqi, Is; Sedgwick, B; Barroso, I; Lindahl, T; Ponting, Cp; Ashcroft, Fm; O'rahilly, S; Schofield, Cj (2007). "The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase". Science (New York, N.Y.). 318 (5855): 1469–72. doi:10.1126/science.1151710. ISSN 0036-8075. PMC 2668859. PMID 17991826. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
12. Ponting, Cp; Hutton, M; Nyborg, A; Baker, M; Jansen, K; Golde, Te (2002). "Identification of a novel family of presenilin homologues" (Free full text). Human molecular genetics. 11 (9): 1037–44. ISSN 0964-6906. PMID 11978763. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
13. Abd, El-Aziz, Mm; Barragan, I; O'driscoll, Ca; Goodstadt, L; Prigmore, E; Borrego, S; Mena, M; Pieras, Ji; El-Ashry, Mf; Safieh, La; Shah, A; Cheetham, Me; Carter, Np; Chakarova, C; Ponting, Cp; Bhattacharya, Ss; Antinolo, G (2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature genetics. 40 (11): 1285–7. doi:10.1038/ng.241. ISSN 1061-4036. PMC 2719291. PMID 18836446. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
14. Dickens, Nj; Beatson, S; Ponting, Cp (2002). "Cadherin-like domains in alpha-dystroglycan, alpha/epsilon-sarcoglycan and yeast and bacterial proteins". Current biology : CB. 12 (6): R197–9. ISSN 0960-9822. PMID 11909544. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
15. Crow, Yj; Leitch, A; Hayward, Be; Garner, A; Parmar, R; Griffith, E; Ali, M; Semple, C; Aicardi, J; Babul-Hirji, R; Baumann, C; Baxter, P; Bertini, E; Chandler, Ke; Chitayat, D; Cau, D; Déry, C; Fazzi, E; Goizet, C; King, Md; Klepper, J; Lacombe, D; Lanzi, G; Lyall, H; Martínez-Frías, Ml; Mathieu, M; Mckeown, C; Monier, A; Oade, Y; Quarrell, Ow; Rittey, Cd; Rogers, Rc; Sanchis, A; Stephenson, Jb; Tacke, U; Till, M; Tolmie, Jl; Tomlin, P; Voit, T; Weschke, B; Woods, Cg; Lebon, P; Bonthron, Dt; Ponting, Cp; Jackson, Ap (2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature genetics. 38 (8): 910–6. doi:10.1038/ng1842. ISSN 1061-4036. PMID 16845400. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)

External links

• Chris Ponting's homepage in the MRC Functional Genomics Unit
• Darwin 2009
• Discussing the platypus genome

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