Pethidine intermediate A: Difference between revisions

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Revision as of 01:19, 6 February 2011

Pharmaceutical compound

Pethidine intermediate A
Clinical data

Routes of administration	N/A
ATC code	none
Legal status
Legal status	US: Schedule II
Identifiers
IUPAC name 1-methyl-4-phenylpiperidine-4-carbonitrile
CAS Number	3627-62-1
PubChem CID	62513
CompTox Dashboard (EPA)	DTXSID50189814
ECHA InfoCard	100.020.771
Chemical and physical data
Formula	C₁₃H₁₆N₂
Molar mass	200.28 g/mol g·mol

Pethidine intermediate A is a 4-phenyl piperidine derivative that is a precursor to the opioid analgesic drug pethidine (meperidine). It is not known to have any analgesic activity in its own right, however other derivatives of pethidine with a 4-cyano group in place of the carboxylate ethyl ester have been found to be active, so pethidine intermediate A might also show opioid effects.

References

Lomenzo SA, Rhoden JB, Izenwasser S, Wade D, Kopajtic T, Katz JL, Trudell ML. Synthesis and Biological Evaluation of Meperidine Analogues at Monoamine Transporters. Journal of Medicinal Chemistry. 2005; 48:1336-1343.

Opioid receptor modulators

μ-opioid
(MOR)

Agonists
(abridged;
full list)