| Revision as of 20:15, 29 August 2008 editAyrton Prost (talk | contribs)Extended confirmed users, Rollbackers5,650 edits AfD: Nominated for deletion; see Misplaced Pages:Articles for deletion/Apricitabine← Previous edit | Revision as of 20:46, 29 August 2008 edit undoFvasconcellos (talk | contribs)Autopatrolled, Administrators30,939 edits adding PK information to drugboxNext edit → | ||
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| | C=8 | H=11 | N=3 | O=3 | S=1 | | C=8 | H=11 | N=3 | O=3 | S=1 | ||
| | molecular_weight = 229.256 g/mol | | molecular_weight = 229.256 g/mol | ||
| | bioavailability= | | bioavailability= 65 to 80% | ||
| | |
| protein_bound = < 4% | ||
| | metabolism = To apricitabine triphosphate | |||
| | elimination_half-life= | | elimination_half-life= 6 to 7 hours (triphosphate) | ||
| | excretion = | | excretion = ] | ||
| | pregnancy_category = | | pregnancy_category = | ||
| | legal_status = | | legal_status = Investigational | ||
| | routes_of_administration= | | routes_of_administration= Oral | ||
| }} | }} | ||
| '''Apricitabine''' is an experimental ] (NRTI). | '''Apricitabine''' (], codenamed '''AVX754''' and '''SPD754''') is an experimental ] (NRTI). | ||
| It was first developed by BioChem Pharma (where it was called BCH10618). BioChem Pharma was then sold the Shire Pharmaceuticals (where the drug was called SPD754). Shire then sold the rights to develop the drug to Avexa, an Australian pharmaceutical company.<ref></ref> | It was first developed by BioChem Pharma (where it was called BCH10618). BioChem Pharma was then sold the Shire Pharmaceuticals (where the drug was called SPD754). Shire then sold the rights to develop the drug to Avexa, an Australian pharmaceutical company.<ref></ref> | ||
Revision as of 20:46, 29 August 2008
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| Clinical data | |
|---|---|
| Routes of administration | Oral |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | 65 to 80% |
| Protein binding | < 4% |
| Metabolism | To apricitabine triphosphate |
| Elimination half-life | 6 to 7 hours (triphosphate) |
| Excretion | Renal |
| Identifiers | |
IUPAC name
| |
| CAS Number | |
| PubChem CID | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C8H11N3O3S |
| Molar mass | 229.256 g/mol g·mol |
Apricitabine (INN, codenamed AVX754 and SPD754) is an experimental nucleoside reverse transcriptase inhibitor (NRTI).
It was first developed by BioChem Pharma (where it was called BCH10618). BioChem Pharma was then sold the Shire Pharmaceuticals (where the drug was called SPD754). Shire then sold the rights to develop the drug to Avexa, an Australian pharmaceutical company.
References
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