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{{Short description|British computational biologist}}
{{Orphan|date=February 2009}}

{{Infobox_Scientist
{{Use dmy dates|date=May 2017}}
| name = Chris Ponting
{{Use British English|date=May 2017}}
| image =
{{Infobox scientist
| image_width =
| name = Chris Ponting
| caption =
| birth_name = Christopher Paul Ponting
| birth_date =
| image = Chris Ponting.jpg
| birth_place =
| image_size =
| death_date =
| caption =
| death_place =
| birth_date =
| residence = ]
| birth_place =
| nationality = British
| death_date =
| field = ]
| death_place =
| work_institution = ]
| nationality = British
| alma_mater = ], ]
| fields = {{Plainlist|
| doctoral_advisor =
* ]
* ]}}
| work_institution = ]
| alma_mater = {{Plainlist|
* ] (BA, DPhil)
* ] (MSc)}}
| doctoral_advisor =
| thesis_title = Structural Studies of Plasminogen and Related Proteins
| thesis_url = http://solo.bodleian.ox.ac.uk/primo_library/libweb/action/display.do?doc=oxfaleph015982470
| thesis_year = 1992
| doctoral_students = | doctoral_students =
| known_for = ] | known_for = SMART<ref>{{Cite journal
| last1 = Schultz | first1 = J.
| prizes =
| last2 = Milpetz | first2 = F.
| footnotes =
| last3 = Bork | first3 = P.
| author-link3 = Peer Bork
| last4 = Ponting | first4 = C.
| author-link4= Chris Ponting
| title = SMART, a simple modular architecture research tool: Identification of signaling domains
| journal = Proceedings of the National Academy of Sciences of the United States of America
| volume = 95
| issue = 11
| pages = 5857–5864
| year = 1998
| pmid = 9600884
| pmc = 34487
|bibcode = 1998PNAS...95.5857S |doi = 10.1073/pnas.95.11.5857 | doi-access = free
}}</ref>
| prizes =
| footnotes =
| website = {{URL|https://www.ed.ac.uk/mrc-human-genetics-unit/research/ponting-group}}
}} }}


'''Chris P. Ponting''' is a British ], specializing in the ] and function of ] and ]. He is currently Professor of ] at the ] and group leader in the ] Functional Genomics Unit, and is affiliated with the ], and Oxford's Department of ], ] and ]. After receiving his ] and ] in physics from ] and the ], respectively, he returned to ], completing his ] in ] in 1991.<ref><nowiki>http://users.ox.ac.uk/~mrcfgu/ponting/cpp.html</nowiki>{{dead link}}</ref> '''Christopher Paul Ponting''' is a British ], specializing in the ] and function of ] and ]. He is currently Chair of Medical Bioinformatics at the ] and group leader in the ] Human Genetics Unit. He is also an Associate Faculty member of the ], a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the ].<ref>{{Cite news|url=https://www.rse.org.uk/fellow/chris-ponting/|title=Professor Christopher Paul Ponting FMedSci FRSE - The Royal Society of Edinburgh|work=The Royal Society of Edinburgh|access-date=2018-03-14|language=en-GB}}</ref> His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics.<ref name="scopus">{{Scopus|id=7004959561}}</ref><ref>{{cite journal | doi = 10.1038/nrg3642 | title=Sequencing depth and coverage: key considerations in genomic analyses | journal=Nature Reviews Genetics | date=2014 | volume=15 | issue=2 | pages=121–132 | first=David | last=Sims | pmid=24434847| s2cid=13325739 }}</ref><ref>{{cite journal | doi = 10.1371/journal.pgen.1004525 | title=8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage | journal=PLOS Genetics | date=2014 | volume=10 | issue=7 | pages=e1004525 | first=Chris M. | last=Rands | pmid=25057982 | pmc=4109858 | doi-access=free }}</ref><ref>{{Cite journal
| pmid = 15057822
| year = 2004
| last1 = Gibbs
| first1 = R. A.
| title = Genome sequence of the Brown Norway rat yields insights into mammalian evolution
| journal = Nature
| volume = 428
| issue = 6982
| pages = 493–521
| last2 = Weinstock
| first2 = G. M.
| last3 = Metzker
| first3 = M. L.
| last4 = Muzny
| first4 = D. M.
| last5 = Sodergren
| first5 = E. J.
| last6 = Scherer
| first6 = S
| last7 = Scott
| first7 = G
| last8 = Steffen
| first8 = D
| last9 = Worley
| first9 = K. C.
| last10 = Burch
| first10 = P. E.
| last11 = Okwuonu
| first11 = G
| last12 = Hines
| first12 = S
| last13 = Lewis
| first13 = L
| last14 = Deramo
| first14 = C
| last15 = Delgado
| first15 = O
| last16 = Dugan-Rocha
| first16 = S
| last17 = Miner
| first17 = G
| last18 = Morgan
| first18 = M
| last19 = Hawes
| first19 = A
| last20 = Gill
| first20 = R
| last22 = Holt
| first22 = R. A.
| last23 = Adams
| first23 = M. D.
| last24 = Amanatides
| first24 = P. G.
| last25 = Baden-Tillson
| first25 = H
| last26 = Barnstead
| first26 = M
| last27 = Chin
| first27 = S
| last28 = Evans
| first28 = C. A.
| last29 = Ferriera
| first29 = S
| last30 = Fosler
| first30 = C
| display-authors = 29
| doi = 10.1038/nature02426
| bibcode = 2004Natur.428..493G
| author21 = Celera
| doi-access = free
}}</ref><ref>{{Cite journal | pmid = 17994087| year = 2007| last1 = Drosophila 12 Genomes| first1 = Consortium| title = Evolution of genes and genomes on the Drosophila phylogeny| journal = Nature| volume = 450| issue = 7167| pages = 203–18| last2 = Clark| first2 = A. G.| last3 = Eisen| first3 = M. B.| author-link3 = Michael Eisen| last4 = Smith| first4 = D. R.| last5 = Bergman| first5 = C. M.| last6 = Oliver| first6 = B| last7 = Markow| first7 = T. A.| last8 = Kaufman| first8 = T. C.| last9 = Kellis| first9 = M| last10 = Gelbart| first10 = W| last11 = Iyer| first11 = V. N.| last12 = Pollard| first12 = D. A.| last13 = Sackton| first13 = T. B.| last14 = Larracuente| first14 = A. M.| last15 = Singh| first15 = N. D.| last16 = Abad| first16 = J. P.| last17 = Abt| first17 = D. N.| last18 = Adryan| first18 = B| last19 = Aguade| first19 = M| last20 = Akashi| first20 = H| last21 = Anderson| first21 = W. W.| last22 = Aquadro| first22 = C. F.| last23 = Ardell| first23 = D. H.| last24 = Arguello| first24 = R| last25 = Artieri| first25 = C. G.| last26 = Barbash| first26 = D. A.| last27 = Barker| first27 = D| last28 = Barsanti| first28 = P| last29 = Batterham| first29 = P| last30 = Batzoglou| first30 = S| display-authors = 29| doi = 10.1038/nature06341|bibcode = 2007Natur.450..203C | doi-access = free}}</ref><ref>{{Cite journal
| pmid = 12520011
| pmc = 165493
| year = 2003
| last1 = Mulder
| first1 = N. J.
| title = The InterPro Database, 2003 brings increased coverage and new features
| journal = Nucleic Acids Research
| volume = 31
| issue = 1
| pages = 315–8
| last2 = Apweiler
| first2 = R
| author-link2 = Rolf Apweiler
| last3 = Attwood
| first3 = T. K.
| author-link3 = Terri Attwood
| last4 = Bairoch
| first4 = A
| author-link4 = Amos Bairoch
| last5 = Barrell
| first5 = D
| last6 = Bateman
| first6 = A
| author-link6 = Alex Bateman
| last7 = Binns
| first7 = D
| last8 = Biswas
| first8 = M
| last9 = Bradley
| first9 = P
| last10 = Bork
| first10 = P
| author-link10 = Peer Bork
| last11 = Bucher
| first11 = P
| last12 = Copley
| first12 = R. R.
| last13 = Courcelle
| first13 = E
| last14 = Das
| first14 = U
| last15 = Durbin
| first15 = R
| author-link15 = Richard M. Durbin
| last16 = Falquet
| first16 = L
| last17 = Fleischmann
| first17 = W
| last18 = Griffiths-Jones
| first18 = S
| last19 = Haft
| first19 = D
| last20 = Harte
| first20 = N
| last21 = Hulo
| first21 = N
| last22 = Kahn
| first22 = D
| last23 = Kanapin
| first23 = A
| last24 = Krestyaninova
| first24 = M
| last25 = Lopez
| first25 = R
| last26 = Letunic
| first26 = I
| last27 = Lonsdale
| first27 = D
| last28 = Silventoinen
| first28 = V.
| last29 = Orchard
| first29 = S. E.
| last30 = Pagni
| first30 = M.
| last31 = Pagni
| first31 = Marco
| last32 = Peyruc
| first32 = D.
| last33 = Ponting
| first33 = C.P.
| author-link33 =Chris Ponting
| last34 = Selengut
| first34 = J.D.
| last35 = Servant
| first35 = F.
| last36 = Sigrist
| first36 = C.J.A.
| last37 = Vaughan
| first37 = R.
| last38 = Zdobnov
| first38 = E.M.
| doi=10.1093/nar/gkg046
}}</ref> Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses.<ref name="BCROPodcast">''''. Episode 2, 2020.</ref>


==Education==
Prof. Ponting contributed to the ],<ref name="pmid11237011">{{cite journal |pmid=11237011}}</ref> and did much of the sequence comparison for the ],<ref>{{cite journal |pmid=12466850}}</ref> ],<ref>{{cite news |first=Jonathan |last=Amos |url=http://news.bbc.co.uk/1/hi/sci/tech/3586573.stm |title=Rat's 'life code' read by science |publisher=] |date={{Date|2004-03-31|mdy}} |accessdate={{Date|2008-12-19|mdy}}}}</ref> ],<ref>{{cite news |url=http://news.bbc.co.uk/1/hi/sci/tech/4079283.stm |title=Chicken gives up genetic secrets |publisher=] |date={{Date|2004-12-09|mdy}} |accessdate={{Date|2008-12-19|mdy}}}}</ref> ],<ref>{{cite journal |pmid=16341006}}</ref> ],<ref>{{cite journal |pmid=17495919}}</ref> and ]<ref>{{cite news |first=Helen |last=Briggs |url=http://news.bbc.co.uk/1/hi/sci/tech/7385949.stm |title=Platypus genetic code unravelled |publisher=] |date={{Date|2008-05-07|mdy}} |accessdate={{Date|2008-12-19|mdy}}}}</ref> Genome Projects. He has also used ] to contribute directly to the understanding of ]<ref>{{cite journal |pmid=10949293}}</ref> and the genetics of numerous conditions including ],<ref>{{cite journal |pmid=12754510}}</ref> ],<ref>{{cite journal |pmid=17991826}}</ref> ],<ref>{{cite journal |pmid=11978763}}</ref> ],<ref>{{cite journal |pmid=18836446}}</ref> ],<ref>{{cite journal |pmid=11909544}}</ref> and ].<ref>{{cite journal |pmid=16845400}}</ref>
After receiving his ] and ] in physics from ] and the ], respectively, he returned to Oxford, completing his ] in ] in 1992 on structural studies of ]ogen.<ref name=pontingphd>{{cite thesis |degree=DPhil |first=Christopher Paul|last=Ponting |title=Structural Studies of Plasminogen and Related Proteins |publisher=University of Oxford |date=1992 |url=http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386861|oclc=556763136}}</ref><ref>{{cite web |url=http://www.mrcfgu.ox.ac.uk/research/chris-p-ponting|archive-url=https://web.archive.org/web/20140407182834/http://www.mrcfgu.ox.ac.uk/research/chris-p-ponting |title= Prof. Chris P Ponting BA MSc DPhil |archive-date=2014-04-07 |publisher=University of Oxford}}</ref>

==Research==
Ponting contributed to the ],<ref name="pmid11237011">{{Cite journal | first1 = E. S.
| last1 = Lander
| author-link1 = Eric Lander
| last2 = Linton | first2 = M.
| last3 = Birren | first3 = B.
| last4 = Nusbaum | first4 = C.
| last5 = Zody | first5 = C.
| last6 = Baldwin | first6 = J.
| last7 = Devon | first7 = K.
| last8 = Dewar | first8 = K.
| last9 = Doyle | first9 = M. | last10 = Fitzhugh | first10 = W. | last11 = Funke | first11 = R. | last12 = Gage | first12 = D. | last13 = Harris | first13 = K. | last14 = Heaford | first14 = A. | last15 = Howland | first15 = J. | last16 = Kann | first16 = L. | last17 = Lehoczky | first17 = J. | last18 = Levine | first18 = R. | last19 = McEwan | first19 = P. | last20 = McKernan | first20 = K. | last21 = Meldrim | first21 = J. | last22 = Mesirov | first22 = J. P. | last23 = Miranda | first23 = C. | last24 = Morris | first24 = W. | last25 = Naylor | first25 = J. | last26 = Raymond | first26 = C. | last27 = Rosetti | first27 = M. | last28 = Santos | first28 = R. | last29 = Sheridan | first29 = A. | last30 = Sougnez | first30 = C. | display-authors = 29
| title = Initial sequencing and analysis of the human genome
| journal = Nature
| volume = 409
| issue = 6822
| pages = 860–921
| date =Feb 2001
| issn = 0028-0836
| pmid = 11237011
| doi = 10.1038/35057062|bibcode = 2001Natur.409..860L | doi-access = free | hdl = 2027.42/62798 | hdl-access = free }}</ref> and participated in sequence comparison for the ],<ref>{{Cite journal | last1 = Chinwalla | first1 = A. T. | last2 = Waterston | first2 = L. L. | last3 = Lindblad-Toh | first3 = K. D. | last4 = Birney | first4 = G. A. | last5 = Rogers | first5 = L. A. | last6 = Abril | first6 = R. S. | last7 = Agarwal | first7 = T. A. | last8 = Agarwala | first8 = L. W. | last9 = Ainscough | first9 = E. R. | last10 = Alexandersson | doi = 10.1038/nature01262 | first10 = J. D. | last11 = An | first11 = T. L. | last12 = Antonarakis | first12 = W. E. | last13 = Attwood | first13 = J. O. | last14 = Baertsch | first14 = M. N. | last15 = Bailey | first15 = K. H. | last16 = Barlow | first16 = C. S. | last17 = Beck | first17 = T. C. | last18 = Berry | first18 = B. | last19 = Birren | first19 = J. | last20 = Bloom | first20 = E. | last21 = Bork | first21 = R. H. | last22 = Botcherby | first22 = M. C. | last23 = Bray | first23 = R. K. | last24 = Brent | first24 = S. P. | last25 = Brown | first25 = P. | last26 = Brown | first26 = E. | last27 = Bult | first27 = B. | last28 = Burton | first28 = T. | last29 = Butler | first29 = D. G. | last30 = Campbell | first30 = J. | title = Initial sequencing and comparative analysis of the mouse genome | journal = Nature | volume = 420 | issue = 6915 | pages = 520–562 | year = 2002 | pmid = 12466850 |bibcode = 2002Natur.420..520W | display-authors = 29 | doi-access = free }}</ref> ],<ref>{{cite news |first=Jonathan |last=Amos |url=http://news.bbc.co.uk/1/hi/sci/tech/3586573.stm |title=Rat's 'life code' read by science |work=] |date=31 March 2004 |access-date=19 December 2008}}</ref> chicken,<ref>{{cite news |url=http://news.bbc.co.uk/1/hi/sci/tech/4079283.stm |title=Chicken gives up genetic secrets |work=] |date=9 December 2004 |access-date=19 December 2008}}</ref> dog,<ref>{{Cite journal | last1 = Lindblad-Toh | first1 = K. | last2 = Wade | first2 = C. M. | last3 = Mikkelsen | first3 = T. S. | last4 = Karlsson | first4 = E. K. | last5 = Jaffe | first5 = D. B. | last6 = Kamal | first6 = M. | last7 = Clamp | first7 = M. | last8 = Chang | first8 = J. L. | last9 = Kulbokas | first9 = E. J. | last10 = Zody | doi = 10.1038/nature04338 | first10 = M. C. | last11 = Mauceli | first11 = E. | last12 = Xie | first12 = X. | last13 = Breen | first13 = M. | last14 = Wayne | first14 = R. K. | last15 = Ostrander | first15 = E. A. | last16 = Ponting | first16 = C. P. | last17 = Galibert | first17 = F. | last18 = Smith | first18 = D. R. | last19 = Dejong | first19 = P. J. | last20 = Kirkness | first20 = E. | last21 = Alvarez | first21 = P. | last22 = Biagi | first22 = T. | last23 = Brockman | first23 = W. | last24 = Butler | first24 = J. | last25 = Chin | first25 = C. W. | last26 = Cook | first26 = A. | last27 = Cuff | first27 = J. | last28 = Daly | first28 = M. J. | last29 = Decaprio | first29 = D. | last30 = Gnerre | first30 = S. | title = Genome sequence, comparative analysis and haplotype structure of the domestic dog | journal = Nature | volume = 438 | issue = 7069 | pages = 803–819 | year = 2005 | pmid = 16341006| bibcode = 2005Natur.438..803L | display-authors = 29 | doi-access = free }}</ref> ],<ref>{{Cite journal
| last1 = Mikkelsen | first1 = T. S.
| last2 = Wakefield | first2 = M. J.
| last3 = Aken | first3 = B.
| last4 = Amemiya | first4 = C. T.
| last5 = Chang | first5 = J. L.
| last6 = Duke | first6 = S.
| last7 = Garber | first7 = M.
| last8 = Gentles | first8 = A. J.
| last9 = Goodstadt | first9 = L.
| last10 = Heger
| doi = 10.1038/nature05805 | first10 = A.
| last11 = Jurka | first11 = J.
| last12 = Kamal | first12 = M.
| last13 = Mauceli | first13 = E.
| last14 = Searle | first14 = S. M. J.
| last15 = Sharpe | first15 = T.
| last16 = Baker | first16 = M. L.
| last17 = Batzer | first17 = M. A.
| last18 = Benos | first18 = P. V.
| last19 = Belov | first19 = K.
| last20 = Clamp | first20 = M.
| last21 = Cook | first21 = A.
| last22 = Cuff | first22 = J.
| last23 = Das | first23 = R.
| last24 = Davidow | first24 = L.
| last25 = Deakin | first25 = J. E.
| last26 = Fazzari | first26 = M. J.
| last27 = Glass | first27 = J. L.
| last28 = Grabherr | first28 = M.
| last29 = Greally | first29 = J. M.
| last30 = Gu | first30 = W.
| title = Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
| journal = Nature
| volume = 447
| issue = 7141
| pages = 167–177
| year = 2007
| pmid = 17495919
|bibcode = 2007Natur.447..167M | display-authors = 29
| doi-access = free
| hdl = 1885/57171
| hdl-access = free
}}</ref> and ]<ref>{{Cite journal | last1 = Warren | first1 = W. C. | last2 = Hillier | first2 = L. W. | last3 = Marshall Graves | first3 = J. A. | last4 = Birney | first4 = E. | author-link4 = Ewan Birney| last5 = Ponting | first5 = C. P. | author-link5 = Chris Ponting| last6 = Grützner | first6 = F. | last7 = Belov | first7 = K. | last8 = Miller | first8 = W. | last9 = Clarke | first9 = L. | last10 = Chinwalla | doi = 10.1038/nature06936 | first10 = A. T. | last11 = Yang | first11 = S. P. | last12 = Heger | first12 = A. | last13 = Locke | first13 = D. P. | last14 = Miethke | first14 = P. | last15 = Waters | first15 = P. D. | last16 = Veyrunes | first16 = F. D. R. | last17 = Fulton | first17 = L. | last18 = Fulton | first18 = B. | last19 = Graves | first19 = T. | last20 = Wallis | first20 = J. | last21 = Puente | first21 = X. S. | last22 = López-Otín | first22 = C. | last23 = Ordóñez | first23 = G. R. | last24 = Eichler | first24 = E. E. | last25 = Chen | first25 = L. | last26 = Cheng | first26 = Z. | last27 = Deakin | first27 = J. E. | last28 = Alsop | first28 = A. | last29 = Thompson | first29 = K. | last30 = Kirby | first30 = P. | title = Genome analysis of the platypus reveals unique signatures of evolution | journal = Nature | volume = 453 | issue = 7192 | pages = 175–183 | year = 2008 | pmid = 18464734| pmc =2803040 |bibcode = 2008Natur.453..175W | display-authors = 29 }}</ref><ref>http://www.nature.com/nature/videoarchive/platypusgenome/ Discussing the platypus genome</ref><ref>{{cite news |first=Helen |last=Briggs |url=http://news.bbc.co.uk/1/hi/sci/tech/7385949.stm |title=Platypus genetic code unravelled |work=] |date=7 May 2008 |access-date=19 December 2008}}</ref> Genome Projects. He has also used ] to contribute directly to the understanding of ]<ref>{{Cite journal | last1 = Jenuwein | first1 = T. | last2 = Eisenhaber | first2 = S. | last3 = O'Carroll | first3 = F. | last4 = Strahl | first4 = D. N. | last5 = Sun | first5 = B. D. | last6 = Schmid | first6 = Z. W. | last7 = Opravil | first7 = M. | last8 = Mechtler | first8 = S. | last9 = Ponting | first9 = K. | last10 = Allis | first10 = C. P. | last11 = Jenuwein | first11 = C. D. | title = Regulation of chromatin structure by site-specific histone H3 methyltransferases | journal = Nature | volume = 406 | issue = 6796 | pages = 593–599 | doi = 10.1038/35020506 | year = 2000 | pmid = 10949293| bibcode = 2000Natur.406..593R | s2cid = 205008015 }}</ref> and the genetics of numerous conditions including ],<ref>{{Cite journal | last1 = Zhang | first1 = Y. | last2 = Leaves | first2 = N. I. | last3 = Anderson | first3 = G. G. | last4 = Ponting | first4 = C. P. | author-link4 = Chris Ponting| last5 = Broxholme | first5 = J. | last6 = Holt | first6 = R. | last7 = Edser | first7 = P. | last8 = Bhattacharyya | first8 = S. | last9 = Dunham | first9 = A. | last10 = Adcock | doi = 10.1038/ng1166 | first10 = I. M. | last11 = Pulleyn | first11 = L. | last12 = Barnes | first12 = P. J. | last13 = Harper | first13 = J. I. | last14 = Abecasis | first14 = G. A. | last15 = Cardon | first15 = L. | last16 = White | first16 = M. | last17 = Burton | first17 = J. | last18 = Matthews | first18 = L. | last19 = Mott | first19 = R. | last20 = Ross | first20 = M. | last21 = Cox | first21 = R. | last22 = Moffatt | first22 = M. F. | last23 = Cookson | first23 = W. O. C. M. | title = Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma | journal = Nature Genetics | volume = 34 | issue = 2 | pages = 181–186 | year = 2003 | pmid = 12754510| hdl = 10044/1/57392 | s2cid = 20807679 | hdl-access = free }}</ref> ],<ref>{{Cite journal | last1 = Gerken | first1 = T. | last2 = Girard | first2 = C. A. | last3 = Tung | first3 = Y. -C. L. | last4 = Webby | first4 = C. J. | last5 = Saudek | first5 = V. | last6 = Hewitson | first6 = K. S. | last7 = Yeo | first7 = G. S. H. | last8 = McDonough | first8 = M. A. | last9 = Cunliffe | first9 = S. | last10 = McNeill | doi = 10.1126/science.1151710 | first10 = L. A. | last11 = Galvanovskis | first11 = J. | last12 = Rorsman | first12 = P. | author-link12 = Patrik Rorsman| last13 = Robins | first13 = P. | last14 = Prieur | first14 = X. | last15 = Coll | first15 = A. P. | last16 = Ma | first16 = M. | last17 = Jovanovic | first17 = Z. | last18 = Farooqi | first18 = I. S. | last19 = Sedgwick | first19 = B. | last20 = Barroso | first20 = I. | last21 = Lindahl | first21 = T. | author-link21 = Tomas Lindahl| last22 = Ponting | first22 = C. P. | author-link22 = Chris Ponting| last23 = Ashcroft | first23 = F. M. | author-link23 = Frances Ashcroft| last24 = O'Rahilly | first24 = S. | author-link24 = Stephen O'Rahilly| last25 = Schofield | first25 = C. J. | author-link25 = Christopher J. Schofield | title = The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase | journal = Science | volume = 318 | issue = 5855 | pages = 1469–1472 | year = 2007 | pmid = 17991826| pmc =2668859 |bibcode = 2007Sci...318.1469G }}</ref> ],<ref>{{Cite journal | last1 = Ponting | first1 = C. P. | author-link1 = Chris Ponting| last2 = Hutton | first2 = M. | last3 = Nyborg | first3 = A. | last4 = Baker | first4 = M. | last5 = Jansen | first5 = K. | last6 = Golde | first6 = T. E. | title = Identification of a novel family of presenilin homologues | doi = 10.1093/hmg/11.9.1037 | journal = Human Molecular Genetics | volume = 11 | issue = 9 | pages = 1037–1044 | year = 2002 | pmid = 11978763| doi-access = free }}</ref> ],<ref>{{Cite journal | last1 = Abd El-Aziz | first1 = M. M. | last2 = Barragan | first2 = I. | last3 = O'Driscoll | first3 = C. A. | last4 = Goodstadt | first4 = L. | last5 = Prigmore | first5 = E. | last6 = Borrego | first6 = S. | last7 = Mena | first7 = M. | last8 = Pieras | first8 = J. I. | last9 = El-Ashry | first9 = M. F. | last10 = Safieh | doi = 10.1038/ng.241 | first10 = L. A. | last11 = Shah | first11 = A. | last12 = Cheetham | first12 = M. E. | last13 = Carter | first13 = N. P. | last14 = Chakarova | first14 = C. | last15 = Ponting | first15 = C. P. | last16 = Bhattacharya | first16 = S. S. | last17 = Antinolo | first17 = G. | title = EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa | journal = Nature Genetics | volume = 40 | issue = 11 | pages = 1285–1287 | year = 2008 | pmid = 18836446| pmc =2719291 }}</ref> ],<ref>{{Cite journal | last1 = Dickens | first1 = N. J. | last2 = Beatson | first2 = S. | last3 = Ponting | first3 = C. P. | author-link3 = Chris Ponting| doi = 10.1016/S0960-9822(02)00748-0 | title = Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins | journal = Current Biology | volume = 12 | issue = 6 | pages = R197–R199 | year = 2002 | pmid = 11909544| s2cid = 15872294 | doi-access = free }}</ref> and ].<ref>{{Cite journal | last1 = Crow | first1 = Y. J. | last2 = Leitch | first2 = A. | last3 = Hayward | first3 = B. E. | last4 = Garner | first4 = A. | last5 = Parmar | first5 = R. | last6 = Griffith | first6 = E. | last7 = Ali | first7 = M. | last8 = Semple | first8 = C. | last9 = Aicardi | first9 = J. | last10 = Babul-Hirji | doi = 10.1038/ng1842 | first10 = R. | last11 = Baumann | first11 = C. | last12 = Baxter | first12 = P. | last13 = Bertini | first13 = E. | last14 = Chandler | first14 = K. E. | last15 = Chitayat | first15 = D. | last16 = Cau | first16 = D. | last17 = Déry | first17 = C. | last18 = Fazzi | first18 = E. | last19 = Goizet | first19 = C. | last20 = King | first20 = M. D. | last21 = Klepper | first21 = J. | last22 = Lacombe | first22 = D. | last23 = Lanzi | first23 = G. | last24 = Lyall | first24 = H. | last25 = Martínez-Frías | first25 = M. A. L. | last26 = Mathieu | first26 = M. L. | last27 = McKeown | first27 = C. | last28 = Monier | first28 = A. | last29 = Oade | first29 = Y. | last30 = Quarrell | first30 = O. W. | title = Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection | journal = Nature Genetics | volume = 38 | issue = 8 | pages = 910–916 | year = 2006 | pmid = 16845400 | s2cid = 8076225 }}</ref>

Additionally, his lab is part of ], a genetic study to determine the potential causes of ] (ME/CFS).<ref>'''' MRC Human Genetics Research Unit. July 2021.</ref><ref name="BCROPodcast" />


==References== ==References==
{{Reflist}} {{Reflist|2}}


{{Authority control}}
==External links==
* in the MRC Functional Genomics Unit
*
*


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Latest revision as of 06:11, 6 January 2025

British computational biologist

Chris Ponting
BornChristopher Paul Ponting
NationalityBritish
Alma mater
Known forSMART
Scientific career
Fields
InstitutionsUniversity of Edinburgh
ThesisStructural Studies of Plasminogen and Related Proteins (1992)
Websitewww.ed.ac.uk/mrc-human-genetics-unit/research/ponting-group

Christopher Paul Ponting is a British computational biologist, specializing in the evolution and function of genes and genomes. He is currently Chair of Medical Bioinformatics at the University of Edinburgh and group leader in the MRC Human Genetics Unit. He is also an Associate Faculty member of the Wellcome Trust Sanger Institute, a Fellow of the Academy of Medical Sciences, member of the European Molecular Biology Organisation and Fellow of the Royal Society of Edinburgh. His research focuses on long noncoding RNA function and evolution, on single cell biology and on disease genomics. Outside of science, Chris is an amateur novelist and wrote an unpublished, science fiction novel about engineered viruses.

Education

After receiving his Bachelor of Arts and Master of Science in physics from University of Oxford and the University of British Columbia, respectively, he returned to Oxford, completing his Doctor of Philosophy in biophysics in 1992 on structural studies of plasminogen.

Research

Ponting contributed to the Human Genome Project, and participated in sequence comparison for the mouse, rat, chicken, dog, opossum, and platypus Genome Projects. He has also used comparative genomics to contribute directly to the understanding of chromatin structure and the genetics of numerous conditions including asthma, obesity, Alzheimer's disease, retinitis pigmentosa, muscular dystrophies, and Aicardi–Goutières syndrome.

Additionally, his lab is part of DecodeME, a genetic study to determine the potential causes of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

References

  1. Schultz, J.; Milpetz, F.; Bork, P.; Ponting, C. (1998). "SMART, a simple modular architecture research tool: Identification of signaling domains". Proceedings of the National Academy of Sciences of the United States of America. 95 (11): 5857–5864. Bibcode:1998PNAS...95.5857S. doi:10.1073/pnas.95.11.5857. PMC 34487. PMID 9600884.
  2. "Professor Christopher Paul Ponting FMedSci FRSE - The Royal Society of Edinburgh". The Royal Society of Edinburgh. Retrieved 14 March 2018.
  3. Chris Ponting's publications indexed by the Scopus bibliographic database. (subscription required)
  4. Sims, David (2014). "Sequencing depth and coverage: key considerations in genomic analyses". Nature Reviews Genetics. 15 (2): 121–132. doi:10.1038/nrg3642. PMID 24434847. S2CID 13325739.
  5. Rands, Chris M. (2014). "8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage". PLOS Genetics. 10 (7): e1004525. doi:10.1371/journal.pgen.1004525. PMC 4109858. PMID 25057982.
  6. Gibbs, R. A.; Weinstock, G. M.; Metzker, M. L.; Muzny, D. M.; Sodergren, E. J.; Scherer, S; Scott, G; Steffen, D; Worley, K. C.; Burch, P. E.; Okwuonu, G; Hines, S; Lewis, L; Deramo, C; Delgado, O; Dugan-Rocha, S; Miner, G; Morgan, M; Hawes, A; Gill, R; Celera; Holt, R. A.; Adams, M. D.; Amanatides, P. G.; Baden-Tillson, H; Barnstead, M; Chin, S; Evans, C. A.; Ferriera, S; et al. (2004). "Genome sequence of the Brown Norway rat yields insights into mammalian evolution". Nature. 428 (6982): 493–521. Bibcode:2004Natur.428..493G. doi:10.1038/nature02426. PMID 15057822.
  7. Drosophila 12 Genomes, Consortium; Clark, A. G.; Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.; Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007). "Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18. Bibcode:2007Natur.450..203C. doi:10.1038/nature06341. PMID 17994087.{{cite journal}}: CS1 maint: numeric names: authors list (link)
  8. Mulder, N. J.; Apweiler, R; Attwood, T. K.; Bairoch, A; Barrell, D; Bateman, A; Binns, D; Biswas, M; Bradley, P; Bork, P; Bucher, P; Copley, R. R.; Courcelle, E; Das, U; Durbin, R; Falquet, L; Fleischmann, W; Griffiths-Jones, S; Haft, D; Harte, N; Hulo, N; Kahn, D; Kanapin, A; Krestyaninova, M; Lopez, R; Letunic, I; Lonsdale, D; Silventoinen, V.; Orchard, S. E.; Pagni, M.; Pagni, Marco; Peyruc, D.; Ponting, C.P.; Selengut, J.D.; Servant, F.; Sigrist, C.J.A.; Vaughan, R.; Zdobnov, E.M. (2003). "The InterPro Database, 2003 brings increased coverage and new features". Nucleic Acids Research. 31 (1): 315–8. doi:10.1093/nar/gkg046. PMC 165493. PMID 12520011.
  9. ^ The Bioinformatics CRO Podcast. Episode 2, 2020.
  10. Ponting, Christopher Paul (1992). Structural Studies of Plasminogen and Related Proteins (DPhil thesis). University of Oxford. OCLC 556763136.
  11. "Prof. Chris P Ponting BA MSc DPhil". University of Oxford. Archived from the original on 7 April 2014.
  12. Lander, E. S.; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (February 2001). "Initial sequencing and analysis of the human genome". Nature. 409 (6822): 860–921. Bibcode:2001Natur.409..860L. doi:10.1038/35057062. hdl:2027.42/62798. ISSN 0028-0836. PMID 11237011.
  13. Chinwalla, A. T.; Waterston, L. L.; Lindblad-Toh, K. D.; Birney, G. A.; Rogers, L. A.; Abril, R. S.; Agarwal, T. A.; Agarwala, L. W.; Ainscough, E. R.; Alexandersson, J. D.; An, T. L.; Antonarakis, W. E.; Attwood, J. O.; Baertsch, M. N.; Bailey, K. H.; Barlow, C. S.; Beck, T. C.; Berry, B.; Birren, J.; Bloom, E.; Bork, R. H.; Botcherby, M. C.; Bray, R. K.; Brent, S. P.; Brown, P.; Brown, E.; Bult, B.; Burton, T.; Butler, D. G.; et al. (2002). "Initial sequencing and comparative analysis of the mouse genome". Nature. 420 (6915): 520–562. Bibcode:2002Natur.420..520W. doi:10.1038/nature01262. PMID 12466850.
  14. Amos, Jonathan (31 March 2004). "Rat's 'life code' read by science". BBC News. Retrieved 19 December 2008.
  15. "Chicken gives up genetic secrets". BBC News. 9 December 2004. Retrieved 19 December 2008.
  16. Lindblad-Toh, K.; Wade, C. M.; Mikkelsen, T. S.; Karlsson, E. K.; Jaffe, D. B.; Kamal, M.; Clamp, M.; Chang, J. L.; Kulbokas, E. J.; Zody, M. C.; Mauceli, E.; Xie, X.; Breen, M.; Wayne, R. K.; Ostrander, E. A.; Ponting, C. P.; Galibert, F.; Smith, D. R.; Dejong, P. J.; Kirkness, E.; Alvarez, P.; Biagi, T.; Brockman, W.; Butler, J.; Chin, C. W.; Cook, A.; Cuff, J.; Daly, M. J.; Decaprio, D.; et al. (2005). "Genome sequence, comparative analysis and haplotype structure of the domestic dog". Nature. 438 (7069): 803–819. Bibcode:2005Natur.438..803L. doi:10.1038/nature04338. PMID 16341006.
  17. Mikkelsen, T. S.; Wakefield, M. J.; Aken, B.; Amemiya, C. T.; Chang, J. L.; Duke, S.; Garber, M.; Gentles, A. J.; Goodstadt, L.; Heger, A.; Jurka, J.; Kamal, M.; Mauceli, E.; Searle, S. M. J.; Sharpe, T.; Baker, M. L.; Batzer, M. A.; Benos, P. V.; Belov, K.; Clamp, M.; Cook, A.; Cuff, J.; Das, R.; Davidow, L.; Deakin, J. E.; Fazzari, M. J.; Glass, J. L.; Grabherr, M.; Greally, J. M.; et al. (2007). "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences". Nature. 447 (7141): 167–177. Bibcode:2007Natur.447..167M. doi:10.1038/nature05805. hdl:1885/57171. PMID 17495919.
  18. Warren, W. C.; Hillier, L. W.; Marshall Graves, J. A.; Birney, E.; Ponting, C. P.; Grützner, F.; Belov, K.; Miller, W.; Clarke, L.; Chinwalla, A. T.; Yang, S. P.; Heger, A.; Locke, D. P.; Miethke, P.; Waters, P. D.; Veyrunes, F. D. R.; Fulton, L.; Fulton, B.; Graves, T.; Wallis, J.; Puente, X. S.; López-Otín, C.; Ordóñez, G. R.; Eichler, E. E.; Chen, L.; Cheng, Z.; Deakin, J. E.; Alsop, A.; Thompson, K.; et al. (2008). "Genome analysis of the platypus reveals unique signatures of evolution". Nature. 453 (7192): 175–183. Bibcode:2008Natur.453..175W. doi:10.1038/nature06936. PMC 2803040. PMID 18464734.
  19. http://www.nature.com/nature/videoarchive/platypusgenome/ Discussing the platypus genome
  20. Briggs, Helen (7 May 2008). "Platypus genetic code unravelled". BBC News. Retrieved 19 December 2008.
  21. Jenuwein, T.; Eisenhaber, S.; O'Carroll, F.; Strahl, D. N.; Sun, B. D.; Schmid, Z. W.; Opravil, M.; Mechtler, S.; Ponting, K.; Allis, C. P.; Jenuwein, C. D. (2000). "Regulation of chromatin structure by site-specific histone H3 methyltransferases". Nature. 406 (6796): 593–599. Bibcode:2000Natur.406..593R. doi:10.1038/35020506. PMID 10949293. S2CID 205008015.
  22. Zhang, Y.; Leaves, N. I.; Anderson, G. G.; Ponting, C. P.; Broxholme, J.; Holt, R.; Edser, P.; Bhattacharyya, S.; Dunham, A.; Adcock, I. M.; Pulleyn, L.; Barnes, P. J.; Harper, J. I.; Abecasis, G. A.; Cardon, L.; White, M.; Burton, J.; Matthews, L.; Mott, R.; Ross, M.; Cox, R.; Moffatt, M. F.; Cookson, W. O. C. M. (2003). "Positional cloning of a quantitative trait locus on chromosome 13q14 that influences immunoglobulin E levels and asthma". Nature Genetics. 34 (2): 181–186. doi:10.1038/ng1166. hdl:10044/1/57392. PMID 12754510. S2CID 20807679.
  23. Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. Bibcode:2007Sci...318.1469G. doi:10.1126/science.1151710. PMC 2668859. PMID 17991826.
  24. Ponting, C. P.; Hutton, M.; Nyborg, A.; Baker, M.; Jansen, K.; Golde, T. E. (2002). "Identification of a novel family of presenilin homologues". Human Molecular Genetics. 11 (9): 1037–1044. doi:10.1093/hmg/11.9.1037. PMID 11978763.
  25. Abd El-Aziz, M. M.; Barragan, I.; O'Driscoll, C. A.; Goodstadt, L.; Prigmore, E.; Borrego, S.; Mena, M.; Pieras, J. I.; El-Ashry, M. F.; Safieh, L. A.; Shah, A.; Cheetham, M. E.; Carter, N. P.; Chakarova, C.; Ponting, C. P.; Bhattacharya, S. S.; Antinolo, G. (2008). "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in autosomal recessive retinitis pigmentosa". Nature Genetics. 40 (11): 1285–1287. doi:10.1038/ng.241. PMC 2719291. PMID 18836446.
  26. Dickens, N. J.; Beatson, S.; Ponting, C. P. (2002). "Cadherin-like domains in α-dystroglycan, α/ε-sarcoglycan and yeast and bacterial proteins". Current Biology. 12 (6): R197 – R199. doi:10.1016/S0960-9822(02)00748-0. PMID 11909544. S2CID 15872294.
  27. Crow, Y. J.; Leitch, A.; Hayward, B. E.; Garner, A.; Parmar, R.; Griffith, E.; Ali, M.; Semple, C.; Aicardi, J.; Babul-Hirji, R.; Baumann, C.; Baxter, P.; Bertini, E.; Chandler, K. E.; Chitayat, D.; Cau, D.; Déry, C.; Fazzi, E.; Goizet, C.; King, M. D.; Klepper, J.; Lacombe, D.; Lanzi, G.; Lyall, H.; Martínez-Frías, M. A. L.; Mathieu, M. L.; McKeown, C.; Monier, A.; Oade, Y.; Quarrell, O. W. (2006). "Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutières syndrome and mimic congenital viral brain infection". Nature Genetics. 38 (8): 910–916. doi:10.1038/ng1842. PMID 16845400. S2CID 8076225.
  28. Chris Ponting Research Group MRC Human Genetics Research Unit. July 2021.
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